Complete Remission of Severe Eosinophilic Otitis Media With Dupilumab: A Case Report

Eosinophilic otitis media (EOM) is a difficult‐to‐treat otitis media (OM) characterized by eosinophilic accumulation in the middle ear mucosa and secretion. Associated sensorineural hearing loss can eventually lead to (functional) deafness. EOM is strongly associated with type 2 inflammation driven...

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Autores principales: van der Lans, Rik J. L., van Spronsen, Erik, Fokkens, Wytske J., Reitsma, Sietze
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Allergy, Rhinology, and Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292739/
https://www.ncbi.nlm.nih.gov/pubmed/34216146
http://dx.doi.org/10.1002/lary.29730
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author van der Lans, Rik J. L.
van Spronsen, Erik
Fokkens, Wytske J.
Reitsma, Sietze
author_facet van der Lans, Rik J. L.
van Spronsen, Erik
Fokkens, Wytske J.
Reitsma, Sietze
author_sort van der Lans, Rik J. L.
collection PubMed
description Eosinophilic otitis media (EOM) is a difficult‐to‐treat otitis media (OM) characterized by eosinophilic accumulation in the middle ear mucosa and secretion. Associated sensorineural hearing loss can eventually lead to (functional) deafness. EOM is strongly associated with type 2 inflammation driven respiratory disease, i.e. asthma and chronic rhinosinusitis with nasal polyps (CRSwNP), for which biological treatment is available. This case report discusses a patient suffering from EOM with severe mixed hearing loss, nearing functional deafness. Dupilumab treatment resulted in complete and enduring remission of the EOM, enabling adequate hearing rehabilitation. Concurrent control of the comorbid asthma and CRSwNP was obtained. Laryngoscope, 131:2649–2651, 2021
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spelling pubmed-92927392022-07-20 Complete Remission of Severe Eosinophilic Otitis Media With Dupilumab: A Case Report van der Lans, Rik J. L. van Spronsen, Erik Fokkens, Wytske J. Reitsma, Sietze Laryngoscope Allergy, Rhinology, and Immunology Eosinophilic otitis media (EOM) is a difficult‐to‐treat otitis media (OM) characterized by eosinophilic accumulation in the middle ear mucosa and secretion. Associated sensorineural hearing loss can eventually lead to (functional) deafness. EOM is strongly associated with type 2 inflammation driven respiratory disease, i.e. asthma and chronic rhinosinusitis with nasal polyps (CRSwNP), for which biological treatment is available. This case report discusses a patient suffering from EOM with severe mixed hearing loss, nearing functional deafness. Dupilumab treatment resulted in complete and enduring remission of the EOM, enabling adequate hearing rehabilitation. Concurrent control of the comorbid asthma and CRSwNP was obtained. Laryngoscope, 131:2649–2651, 2021 John Wiley & Sons, Inc. 2021-07-03 2021-12 /pmc/articles/PMC9292739/ /pubmed/34216146 http://dx.doi.org/10.1002/lary.29730 Text en © 2021 The Authors. The Laryngoscope published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Allergy, Rhinology, and Immunology
van der Lans, Rik J. L.
van Spronsen, Erik
Fokkens, Wytske J.
Reitsma, Sietze
Complete Remission of Severe Eosinophilic Otitis Media With Dupilumab: A Case Report
title Complete Remission of Severe Eosinophilic Otitis Media With Dupilumab: A Case Report
title_full Complete Remission of Severe Eosinophilic Otitis Media With Dupilumab: A Case Report
title_fullStr Complete Remission of Severe Eosinophilic Otitis Media With Dupilumab: A Case Report
title_full_unstemmed Complete Remission of Severe Eosinophilic Otitis Media With Dupilumab: A Case Report
title_short Complete Remission of Severe Eosinophilic Otitis Media With Dupilumab: A Case Report
title_sort complete remission of severe eosinophilic otitis media with dupilumab: a case report
topic Allergy, Rhinology, and Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292739/
https://www.ncbi.nlm.nih.gov/pubmed/34216146
http://dx.doi.org/10.1002/lary.29730
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