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Fat mass and fat‐free mass track from infancy to childhood: New insights in body composition programming in early life

OBJECTIVE: Early life is a critical window for adiposity programming. This study investigated whether fat mass percentage (FM%), fat mass index (FMI), abdominal fat, and fat‐free mass (FFM) in early life track into childhood and whether there are sex differences and differences between infant feedin...

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Autores principales: van Beijsterveldt, Inge A. L. P., de Fluiter, Kirsten S., Breij, Laura M., van der Steen, Manouk, Hokken‐Koelega, Anita C. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292756/
https://www.ncbi.nlm.nih.gov/pubmed/34549538
http://dx.doi.org/10.1002/oby.23271
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author van Beijsterveldt, Inge A. L. P.
de Fluiter, Kirsten S.
Breij, Laura M.
van der Steen, Manouk
Hokken‐Koelega, Anita C. S.
author_facet van Beijsterveldt, Inge A. L. P.
de Fluiter, Kirsten S.
Breij, Laura M.
van der Steen, Manouk
Hokken‐Koelega, Anita C. S.
author_sort van Beijsterveldt, Inge A. L. P.
collection PubMed
description OBJECTIVE: Early life is a critical window for adiposity programming. This study investigated whether fat mass percentage (FM%), fat mass index (FMI), abdominal fat, and fat‐free mass (FFM) in early life track into childhood and whether there are sex differences and differences between infant feeding types. METHODS: Detailed body composition was longitudinally measured by air‐displacement plethysmography, dual‐energy x‐ray absorptiometry, and abdominal ultrasound in 224 healthy, term‐born children. Measurements were divided into tertiles. Odds ratios (OR) of remaining in the highest tertile of FM%, FMI, abdominal subcutaneous and visceral fat, and FFM index (FFMI) were calculated from early life to age 4 years. RESULTS: High FM% and FMI tracked from age 3 and 6 months to age 4 years (OR = 4.34 [p = 0.002] and OR = 6.54 [p < 0.001]). High subcutaneous abdominal fat tracked from age 6 months to age 4 years (OR = 2.30 [p = 0.012]). High FFMI tracked from age 1, 3, and 6 months to age 4 years (OR = 4.16 [p = 0.005], 3.71 [p = 0.004], and 3.36 [p = 0.019]). In non‐exclusively breastfed infants, high FM% tracked from early life to age 4 years, whereas this was not the case for exclusively breastfed infants. There was no tracking in visceral fat or sex differences. CONCLUSIONS: Infants with high FM%, FMI, subcutaneous abdominal fat, and FFMI in early life are likely to remain in the highest tertile at age 4 years. Exclusive breastfeeding for 3 months is potentially protective against having high FM% at age 4 years.
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spelling pubmed-92927562022-07-20 Fat mass and fat‐free mass track from infancy to childhood: New insights in body composition programming in early life van Beijsterveldt, Inge A. L. P. de Fluiter, Kirsten S. Breij, Laura M. van der Steen, Manouk Hokken‐Koelega, Anita C. S. Obesity (Silver Spring) ORIGINAL ARTICLES OBJECTIVE: Early life is a critical window for adiposity programming. This study investigated whether fat mass percentage (FM%), fat mass index (FMI), abdominal fat, and fat‐free mass (FFM) in early life track into childhood and whether there are sex differences and differences between infant feeding types. METHODS: Detailed body composition was longitudinally measured by air‐displacement plethysmography, dual‐energy x‐ray absorptiometry, and abdominal ultrasound in 224 healthy, term‐born children. Measurements were divided into tertiles. Odds ratios (OR) of remaining in the highest tertile of FM%, FMI, abdominal subcutaneous and visceral fat, and FFM index (FFMI) were calculated from early life to age 4 years. RESULTS: High FM% and FMI tracked from age 3 and 6 months to age 4 years (OR = 4.34 [p = 0.002] and OR = 6.54 [p < 0.001]). High subcutaneous abdominal fat tracked from age 6 months to age 4 years (OR = 2.30 [p = 0.012]). High FFMI tracked from age 1, 3, and 6 months to age 4 years (OR = 4.16 [p = 0.005], 3.71 [p = 0.004], and 3.36 [p = 0.019]). In non‐exclusively breastfed infants, high FM% tracked from early life to age 4 years, whereas this was not the case for exclusively breastfed infants. There was no tracking in visceral fat or sex differences. CONCLUSIONS: Infants with high FM%, FMI, subcutaneous abdominal fat, and FFMI in early life are likely to remain in the highest tertile at age 4 years. Exclusive breastfeeding for 3 months is potentially protective against having high FM% at age 4 years. John Wiley and Sons Inc. 2021-09-21 2021-11 /pmc/articles/PMC9292756/ /pubmed/34549538 http://dx.doi.org/10.1002/oby.23271 Text en © 2021 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle ORIGINAL ARTICLES
van Beijsterveldt, Inge A. L. P.
de Fluiter, Kirsten S.
Breij, Laura M.
van der Steen, Manouk
Hokken‐Koelega, Anita C. S.
Fat mass and fat‐free mass track from infancy to childhood: New insights in body composition programming in early life
title Fat mass and fat‐free mass track from infancy to childhood: New insights in body composition programming in early life
title_full Fat mass and fat‐free mass track from infancy to childhood: New insights in body composition programming in early life
title_fullStr Fat mass and fat‐free mass track from infancy to childhood: New insights in body composition programming in early life
title_full_unstemmed Fat mass and fat‐free mass track from infancy to childhood: New insights in body composition programming in early life
title_short Fat mass and fat‐free mass track from infancy to childhood: New insights in body composition programming in early life
title_sort fat mass and fat‐free mass track from infancy to childhood: new insights in body composition programming in early life
topic ORIGINAL ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292756/
https://www.ncbi.nlm.nih.gov/pubmed/34549538
http://dx.doi.org/10.1002/oby.23271
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