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Neural correlates of the impulse dyscontrol domain of mild behavioral impairment
OBJECTIVES: Agitation and aggression are common in dementia and pre‐dementia. The dementia risk syndrome mild behavioral impairment (MBI) includes these symptoms in the impulse dyscontrol domain. However, the neural circuitry associated with impulse dyscontrol in neurodegenerative disease is not wel...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292816/ https://www.ncbi.nlm.nih.gov/pubmed/33778998 http://dx.doi.org/10.1002/gps.5540 |
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author | Gill, Sascha Wang, Meng Mouches, Pauline Rajashekar, Deepthi Sajobi, Tolulope MacMaster, Frank P Smith, Eric E Forkert, Nils D Ismail, Zahinoor |
author_facet | Gill, Sascha Wang, Meng Mouches, Pauline Rajashekar, Deepthi Sajobi, Tolulope MacMaster, Frank P Smith, Eric E Forkert, Nils D Ismail, Zahinoor |
author_sort | Gill, Sascha |
collection | PubMed |
description | OBJECTIVES: Agitation and aggression are common in dementia and pre‐dementia. The dementia risk syndrome mild behavioral impairment (MBI) includes these symptoms in the impulse dyscontrol domain. However, the neural circuitry associated with impulse dyscontrol in neurodegenerative disease is not well understood. The objective of this work was to investigate if regional micro‐ and macro‐structural brain properties were associated with impulse dyscontrol symptoms in older adults with normal cognition, mild cognitive impairment, and Alzheimer's disease (AD). METHODS: Clinical, neuropsychiatric, and T1‐weighted and diffusion‐tensor magnetic resonance imaging (DTI) data from 80 individuals with and 123 individuals without impulse dyscontrol were obtained from the AD Neuroimaging Initiative. Linear mixed effect models were used to assess if impulse dyscontrol was related to regional DTI and volumetric parameters. RESULTS: Impulse dyscontrol was present in 17% of participants with NC, 43% with MCI, and 66% with AD. Impulse dyscontrol was associated with: (1) lower fractional anisotropy (FA), and greater mean, axial, and radial diffusivity in the fornix; (2) lesser FA and greater radial diffusivity in the superior fronto‐occipital fasciculus; (3) greater axial diffusivity in the cingulum; (4) greater axial and radial diffusivity in the uncinate fasciculus; (5) gray matter atrophy, specifically, lower cortical thickness in the parahippocampal gyrus. CONCLUSION: Our findings provide evidence that well‐established atrophy patterns of AD are prominent in the presence of impulse dyscontrol, even when disease status is controlled for, and possibly in advance of dementia. Our findings support the growing evidence for impulse dyscontrol symptoms as an early manifestation of AD. |
format | Online Article Text |
id | pubmed-9292816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92928162022-07-20 Neural correlates of the impulse dyscontrol domain of mild behavioral impairment Gill, Sascha Wang, Meng Mouches, Pauline Rajashekar, Deepthi Sajobi, Tolulope MacMaster, Frank P Smith, Eric E Forkert, Nils D Ismail, Zahinoor Int J Geriatr Psychiatry Research Articles OBJECTIVES: Agitation and aggression are common in dementia and pre‐dementia. The dementia risk syndrome mild behavioral impairment (MBI) includes these symptoms in the impulse dyscontrol domain. However, the neural circuitry associated with impulse dyscontrol in neurodegenerative disease is not well understood. The objective of this work was to investigate if regional micro‐ and macro‐structural brain properties were associated with impulse dyscontrol symptoms in older adults with normal cognition, mild cognitive impairment, and Alzheimer's disease (AD). METHODS: Clinical, neuropsychiatric, and T1‐weighted and diffusion‐tensor magnetic resonance imaging (DTI) data from 80 individuals with and 123 individuals without impulse dyscontrol were obtained from the AD Neuroimaging Initiative. Linear mixed effect models were used to assess if impulse dyscontrol was related to regional DTI and volumetric parameters. RESULTS: Impulse dyscontrol was present in 17% of participants with NC, 43% with MCI, and 66% with AD. Impulse dyscontrol was associated with: (1) lower fractional anisotropy (FA), and greater mean, axial, and radial diffusivity in the fornix; (2) lesser FA and greater radial diffusivity in the superior fronto‐occipital fasciculus; (3) greater axial diffusivity in the cingulum; (4) greater axial and radial diffusivity in the uncinate fasciculus; (5) gray matter atrophy, specifically, lower cortical thickness in the parahippocampal gyrus. CONCLUSION: Our findings provide evidence that well‐established atrophy patterns of AD are prominent in the presence of impulse dyscontrol, even when disease status is controlled for, and possibly in advance of dementia. Our findings support the growing evidence for impulse dyscontrol symptoms as an early manifestation of AD. John Wiley and Sons Inc. 2021-04-09 2021-09 /pmc/articles/PMC9292816/ /pubmed/33778998 http://dx.doi.org/10.1002/gps.5540 Text en © 2021 The Authors. International Journal of Geriatric =Psychiatry published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Gill, Sascha Wang, Meng Mouches, Pauline Rajashekar, Deepthi Sajobi, Tolulope MacMaster, Frank P Smith, Eric E Forkert, Nils D Ismail, Zahinoor Neural correlates of the impulse dyscontrol domain of mild behavioral impairment |
title | Neural correlates of the impulse dyscontrol domain of mild behavioral impairment |
title_full | Neural correlates of the impulse dyscontrol domain of mild behavioral impairment |
title_fullStr | Neural correlates of the impulse dyscontrol domain of mild behavioral impairment |
title_full_unstemmed | Neural correlates of the impulse dyscontrol domain of mild behavioral impairment |
title_short | Neural correlates of the impulse dyscontrol domain of mild behavioral impairment |
title_sort | neural correlates of the impulse dyscontrol domain of mild behavioral impairment |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292816/ https://www.ncbi.nlm.nih.gov/pubmed/33778998 http://dx.doi.org/10.1002/gps.5540 |
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