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First‐in‐human trial to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of STR‐324, a dual enkephalinase inhibitor for pain management

AIM: Dual enkephalinase inhibitors (DENKIs) are involved in the regulation of nociception via opioid receptors. The novel compound STR‐324 belongs to the DENKI pharmacological class. This first‐in‐human study evaluated the safety, tolerability, pharmacokinetics and pharmacodynamics of STR‐324 in hea...

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Detalles Bibliográficos
Autores principales:	Moss, Laurence M., Berends, Cecile L., van Brummelen, Emilie M. J., Kamerling, Ingrid M. C., Klaassen, Erica S., Bergmann, Kirsten, Ville, Vanessa, Juarez‐Perez, Victor, Benichou, Annie‐Claude, Groeneveld, Geert Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292820/ https://www.ncbi.nlm.nih.gov/pubmed/34046921 http://dx.doi.org/10.1111/bcp.14931

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