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Clinical use of thrombin generation assays
Determining patient's coagulation profile, i.e. detecting a bleeding tendency or the opposite, a thrombotic risk, is crucial for clinicians in many situations. Routine coagulation assays and even more specialized tests may not allow a relevant characterization of the hemostatic balance. In cont...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292855/ https://www.ncbi.nlm.nih.gov/pubmed/34592058 http://dx.doi.org/10.1111/jth.15538 |
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author | Binder, Nikolaus B. Depasse, François Mueller, Julia Wissel, Thomas Schwers, Stephan Germer, Matthias Hermes, Björn Turecek, Peter L. |
author_facet | Binder, Nikolaus B. Depasse, François Mueller, Julia Wissel, Thomas Schwers, Stephan Germer, Matthias Hermes, Björn Turecek, Peter L. |
author_sort | Binder, Nikolaus B. |
collection | PubMed |
description | Determining patient's coagulation profile, i.e. detecting a bleeding tendency or the opposite, a thrombotic risk, is crucial for clinicians in many situations. Routine coagulation assays and even more specialized tests may not allow a relevant characterization of the hemostatic balance. In contrast, thrombin generation assay (TGA) is a global assay allowing the dynamic continuous and simultaneous recording of the combined effects of both thrombin generation and thrombin inactivation. TGA thus reflects the result of procoagulant and anticoagulant activities in blood and plasma. Because of this unique feature, TGA has been widely used in a wide array of settings from both research, clinical and pharmaceutical perspectives. This includes diagnosis, prognosis, prophylaxis, and treatment of inherited and acquired bleeding and thrombotic disorders. In addition, TGA has been shown to provide relevant information for the diagnosis of coagulopathies induced by infectious diseases, comprising also disturbance of the coagulation system in COVID‐19, or for the assessment of early recurrence in breast cancer. This review article aims to document most clinical applications of TGA. |
format | Online Article Text |
id | pubmed-9292855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92928552022-07-20 Clinical use of thrombin generation assays Binder, Nikolaus B. Depasse, François Mueller, Julia Wissel, Thomas Schwers, Stephan Germer, Matthias Hermes, Björn Turecek, Peter L. J Thromb Haemost Review Articles Determining patient's coagulation profile, i.e. detecting a bleeding tendency or the opposite, a thrombotic risk, is crucial for clinicians in many situations. Routine coagulation assays and even more specialized tests may not allow a relevant characterization of the hemostatic balance. In contrast, thrombin generation assay (TGA) is a global assay allowing the dynamic continuous and simultaneous recording of the combined effects of both thrombin generation and thrombin inactivation. TGA thus reflects the result of procoagulant and anticoagulant activities in blood and plasma. Because of this unique feature, TGA has been widely used in a wide array of settings from both research, clinical and pharmaceutical perspectives. This includes diagnosis, prognosis, prophylaxis, and treatment of inherited and acquired bleeding and thrombotic disorders. In addition, TGA has been shown to provide relevant information for the diagnosis of coagulopathies induced by infectious diseases, comprising also disturbance of the coagulation system in COVID‐19, or for the assessment of early recurrence in breast cancer. This review article aims to document most clinical applications of TGA. John Wiley and Sons Inc. 2021-10-08 2021-12 /pmc/articles/PMC9292855/ /pubmed/34592058 http://dx.doi.org/10.1111/jth.15538 Text en © 2021 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Review Articles Binder, Nikolaus B. Depasse, François Mueller, Julia Wissel, Thomas Schwers, Stephan Germer, Matthias Hermes, Björn Turecek, Peter L. Clinical use of thrombin generation assays |
title | Clinical use of thrombin generation assays |
title_full | Clinical use of thrombin generation assays |
title_fullStr | Clinical use of thrombin generation assays |
title_full_unstemmed | Clinical use of thrombin generation assays |
title_short | Clinical use of thrombin generation assays |
title_sort | clinical use of thrombin generation assays |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292855/ https://www.ncbi.nlm.nih.gov/pubmed/34592058 http://dx.doi.org/10.1111/jth.15538 |
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