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Protease‐sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation

Light‐chain (AL) amyloidosis is characterized by deposition of immunoglobulin light chains (LC) as fibrils in target organs. Alongside the full‐length protein, abundant LC fragments are always present in AL deposits. Herein, by combining gel‐based and mass spectrometry analyses, we identified and co...

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Detalles Bibliográficos
Autores principales:	Mazzini, Giulia, Ricagno, Stefano, Caminito, Serena, Rognoni, Paola, Milani, Paolo, Nuvolone, Mario, Basset, Marco, Foli, Andrea, Russo, Rosaria, Merlini, Giampaolo, Palladini, Giovanni, Lavatelli, Francesca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292950/ https://www.ncbi.nlm.nih.gov/pubmed/34482629 http://dx.doi.org/10.1111/febs.16182

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