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A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA

Clamp loaders place circular sliding clamp proteins onto DNA so that clamp-binding partner proteins can synthesize, scan, and repair the genome. DNA with nicks or small single-stranded gaps are common clamp-loading targets in DNA repair, yet these substrates would be sterically blocked given the kno...

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Detalles Bibliográficos
Autores principales:	Liu, Xingchen, Gaubitz, Christl, Pajak, Joshua, Kelch, Brian A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293009/ https://www.ncbi.nlm.nih.gov/pubmed/35731107 http://dx.doi.org/10.7554/eLife.77483

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