Cargando…

Pharmacokinetics of butorphanol in male neutered cats anesthetized with isoflurane

This study characterized the pharmacokinetics of butorphanol in cats anesthetized with isoflurane. Six young healthy male neutered cats were used. Cats were anesthetized with isoflurane in oxygen. Catheters were placed in a jugular vein for blood sampling and in a medial saphenous vein for butorphan...

Descripción completa

Detalles Bibliográficos
Autores principales: Pypendop, Bruno H., Shilo‐Benjamini, Yael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293126/
https://www.ncbi.nlm.nih.gov/pubmed/34558086
http://dx.doi.org/10.1111/jvp.13014
_version_ 1784749545103556608
author Pypendop, Bruno H.
Shilo‐Benjamini, Yael
author_facet Pypendop, Bruno H.
Shilo‐Benjamini, Yael
author_sort Pypendop, Bruno H.
collection PubMed
description This study characterized the pharmacokinetics of butorphanol in cats anesthetized with isoflurane. Six young healthy male neutered cats were used. Cats were anesthetized with isoflurane in oxygen. Catheters were placed in a jugular vein for blood sampling and in a medial saphenous vein for butorphanol and lactated Ringer's solution administration. Butorphanol tartrate (1 mg/kg over 5 min) was administered intravenously. Blood samples were collected prior to butorphanol administration and at various times up to 365 min following administration. Plasma butorphanol concentration was measured using liquid chromatography/tandem mass spectrometry. Compartment models were fitted to the time‐concentration data using nonlinear mixed effect modeling. A three‐compartment model best fitted the data. Typical value (% interindividual variability) for the three volumes of distribution, the metabolic clearance, and the two distribution clearances were 230 (72), 1095 (not estimated), and 2596 (not estimated) ml/kg, and 18.4 (72), 169.6 (52), and 55.0 (43), respectively. Pharmacokinetic simulation suggested that a loading dose (µg/kg) calculated as 0.287 × target plasma concentration in ng/ml (C(T)) followed by intravenous infusions (µg/kg/min) of 0.098 × C(T) for 20 min, 0.049 × C(T) for 40 min, and 0.022 × C(T) thereafter would rapidly achieve and maintain C(T) ± 10% for up to 6.5 h.
format Online
Article
Text
id pubmed-9293126
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-92931262022-07-20 Pharmacokinetics of butorphanol in male neutered cats anesthetized with isoflurane Pypendop, Bruno H. Shilo‐Benjamini, Yael J Vet Pharmacol Ther Pharmacokinetic Report This study characterized the pharmacokinetics of butorphanol in cats anesthetized with isoflurane. Six young healthy male neutered cats were used. Cats were anesthetized with isoflurane in oxygen. Catheters were placed in a jugular vein for blood sampling and in a medial saphenous vein for butorphanol and lactated Ringer's solution administration. Butorphanol tartrate (1 mg/kg over 5 min) was administered intravenously. Blood samples were collected prior to butorphanol administration and at various times up to 365 min following administration. Plasma butorphanol concentration was measured using liquid chromatography/tandem mass spectrometry. Compartment models were fitted to the time‐concentration data using nonlinear mixed effect modeling. A three‐compartment model best fitted the data. Typical value (% interindividual variability) for the three volumes of distribution, the metabolic clearance, and the two distribution clearances were 230 (72), 1095 (not estimated), and 2596 (not estimated) ml/kg, and 18.4 (72), 169.6 (52), and 55.0 (43), respectively. Pharmacokinetic simulation suggested that a loading dose (µg/kg) calculated as 0.287 × target plasma concentration in ng/ml (C(T)) followed by intravenous infusions (µg/kg/min) of 0.098 × C(T) for 20 min, 0.049 × C(T) for 40 min, and 0.022 × C(T) thereafter would rapidly achieve and maintain C(T) ± 10% for up to 6.5 h. John Wiley and Sons Inc. 2021-09-23 2021-11 /pmc/articles/PMC9293126/ /pubmed/34558086 http://dx.doi.org/10.1111/jvp.13014 Text en © 2021 The Authors. Journal of Veterinary Pharmacology and Therapeutics published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Pharmacokinetic Report
Pypendop, Bruno H.
Shilo‐Benjamini, Yael
Pharmacokinetics of butorphanol in male neutered cats anesthetized with isoflurane
title Pharmacokinetics of butorphanol in male neutered cats anesthetized with isoflurane
title_full Pharmacokinetics of butorphanol in male neutered cats anesthetized with isoflurane
title_fullStr Pharmacokinetics of butorphanol in male neutered cats anesthetized with isoflurane
title_full_unstemmed Pharmacokinetics of butorphanol in male neutered cats anesthetized with isoflurane
title_short Pharmacokinetics of butorphanol in male neutered cats anesthetized with isoflurane
title_sort pharmacokinetics of butorphanol in male neutered cats anesthetized with isoflurane
topic Pharmacokinetic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293126/
https://www.ncbi.nlm.nih.gov/pubmed/34558086
http://dx.doi.org/10.1111/jvp.13014
work_keys_str_mv AT pypendopbrunoh pharmacokineticsofbutorphanolinmaleneuteredcatsanesthetizedwithisoflurane
AT shilobenjaminiyael pharmacokineticsofbutorphanolinmaleneuteredcatsanesthetizedwithisoflurane