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A Step toward NRF2‐DNA Interaction Inhibitors by Fragment‐Based NMR Methods

The NRF2 transcription factor is a key regulator in cellular oxidative stress response, and acts as a tumor suppressor. Aberrant activation of NRF2 has been implicated in promoting chemo‐resistance, tumor growth, and metastasis by activating its downstream target genes. Hence, inhibition of NRF2 pro...

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Detalles Bibliográficos
Autores principales:	Brüschweiler, Sven, Fuchs, Julian E., Bader, Gerd, McConnell, Darryl B., Konrat, Robert, Mayer, Moriz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293343/ https://www.ncbi.nlm.nih.gov/pubmed/34524728 http://dx.doi.org/10.1002/cmdc.202100458

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