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Ex vivo microRNA and gene expression profiling of human Tr1‐like cells suggests a role for miR‐92a and ‐125a in the regulation of EOMES and IL‐10R
Ex vivo gene expression and miRNA profiling of Eomes(+)Tr1‐like cells suggested that they represent a differentiation stage that is intermediate between Th1‐cells and cytotoxic CD4(+) T‐cells. Several microRNAs were downregulated in Eomes(+)Tr1‐like cells that might inhibit Tr1‐cell differentiation....
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293355/ https://www.ncbi.nlm.nih.gov/pubmed/34528258 http://dx.doi.org/10.1002/eji.202149315 |
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| author | De Simone, Marco Chirichella, Michele Emming, Stefan Mazzara, Saveria Ranzani, Valeria Gruarin, Paola Moschetti, Giorgia Pulvirenti, Nadia Maglie, Stefano Vasco, Chiara Crosti, Maria Cristina Rossetti, Grazisa Pagani, Massimiliano Abrignani, Sergio Monticelli, Silvia Geginat, Jens |
| author_facet | De Simone, Marco Chirichella, Michele Emming, Stefan Mazzara, Saveria Ranzani, Valeria Gruarin, Paola Moschetti, Giorgia Pulvirenti, Nadia Maglie, Stefano Vasco, Chiara Crosti, Maria Cristina Rossetti, Grazisa Pagani, Massimiliano Abrignani, Sergio Monticelli, Silvia Geginat, Jens |
| author_sort | De Simone, Marco |
| collection | PubMed |
| description | Ex vivo gene expression and miRNA profiling of Eomes(+)Tr1‐like cells suggested that they represent a differentiation stage that is intermediate between Th1‐cells and cytotoxic CD4(+) T‐cells. Several microRNAs were downregulated in Eomes(+)Tr1‐like cells that might inhibit Tr1‐cell differentiation. In particular, miR‐92a targeted Eomes, while miR‐125a inhibited IFN‐g and IL‐10R expression. [Image: see text] |
| format | Online Article Text |
| id | pubmed-9293355 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-92933552022-07-20 Ex vivo microRNA and gene expression profiling of human Tr1‐like cells suggests a role for miR‐92a and ‐125a in the regulation of EOMES and IL‐10R De Simone, Marco Chirichella, Michele Emming, Stefan Mazzara, Saveria Ranzani, Valeria Gruarin, Paola Moschetti, Giorgia Pulvirenti, Nadia Maglie, Stefano Vasco, Chiara Crosti, Maria Cristina Rossetti, Grazisa Pagani, Massimiliano Abrignani, Sergio Monticelli, Silvia Geginat, Jens Eur J Immunol Letters to the Editor Ex vivo gene expression and miRNA profiling of Eomes(+)Tr1‐like cells suggested that they represent a differentiation stage that is intermediate between Th1‐cells and cytotoxic CD4(+) T‐cells. Several microRNAs were downregulated in Eomes(+)Tr1‐like cells that might inhibit Tr1‐cell differentiation. In particular, miR‐92a targeted Eomes, while miR‐125a inhibited IFN‐g and IL‐10R expression. [Image: see text] John Wiley and Sons Inc. 2021-09-28 2021-12 /pmc/articles/PMC9293355/ /pubmed/34528258 http://dx.doi.org/10.1002/eji.202149315 Text en © 2021 The Authors. European Journal of Immunology published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Letters to the Editor De Simone, Marco Chirichella, Michele Emming, Stefan Mazzara, Saveria Ranzani, Valeria Gruarin, Paola Moschetti, Giorgia Pulvirenti, Nadia Maglie, Stefano Vasco, Chiara Crosti, Maria Cristina Rossetti, Grazisa Pagani, Massimiliano Abrignani, Sergio Monticelli, Silvia Geginat, Jens Ex vivo microRNA and gene expression profiling of human Tr1‐like cells suggests a role for miR‐92a and ‐125a in the regulation of EOMES and IL‐10R |
| title | Ex vivo microRNA and gene expression profiling of human Tr1‐like cells suggests a role for miR‐92a and ‐125a in the regulation of EOMES and IL‐10R |
| title_full | Ex vivo microRNA and gene expression profiling of human Tr1‐like cells suggests a role for miR‐92a and ‐125a in the regulation of EOMES and IL‐10R |
| title_fullStr | Ex vivo microRNA and gene expression profiling of human Tr1‐like cells suggests a role for miR‐92a and ‐125a in the regulation of EOMES and IL‐10R |
| title_full_unstemmed | Ex vivo microRNA and gene expression profiling of human Tr1‐like cells suggests a role for miR‐92a and ‐125a in the regulation of EOMES and IL‐10R |
| title_short | Ex vivo microRNA and gene expression profiling of human Tr1‐like cells suggests a role for miR‐92a and ‐125a in the regulation of EOMES and IL‐10R |
| title_sort | ex vivo microrna and gene expression profiling of human tr1‐like cells suggests a role for mir‐92a and ‐125a in the regulation of eomes and il‐10r |
| topic | Letters to the Editor |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293355/ https://www.ncbi.nlm.nih.gov/pubmed/34528258 http://dx.doi.org/10.1002/eji.202149315 |
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