Restriction of SARS-CoV-2 replication in the human placenta

Although SARS-CoV-2 can infect human placental tissue, vertical transmission is rare. Therefore, the placenta may function as a barrier to inhibit viral transmission to the foetus, though the mechanisms remain unclear. In this study, we confirmed the presence of the SARS-CoV-2 genome in human placen...

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Detalles Bibliográficos
Autores principales: Takada, Kazuhide, Shimodai-Yamada, Sayaka, Suzuki, Mayumi, Trinh, Quang Duy, Takano, Chika, Kawakami, Kaori, Asai-Sato, Mikiko, Komatsu, Atsushi, Okahashi, Aya, Nagano, Nobuhiko, Misawa, Toshiya, Yamaguchi, Kyohei, Suzuki, Tadaki, Kawana, Kei, Morioka, Ichiro, Yamada, Hideto, Hayakawa, Satoshi, Hao, Hiroyuki, Komine-Aizawa, Shihoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293377/
https://www.ncbi.nlm.nih.gov/pubmed/35973367
http://dx.doi.org/10.1016/j.placenta.2022.07.010
Descripción
Sumario:Although SARS-CoV-2 can infect human placental tissue, vertical transmission is rare. Therefore, the placenta may function as a barrier to inhibit viral transmission to the foetus, though the mechanisms remain unclear. In this study, we confirmed the presence of the SARS-CoV-2 genome in human placental tissue by in situ hybridization with antisense probes targeting the spike protein; tissue staining was much lower when using sense probes for the spike protein. To the best of our knowledge, this is the first evidence directly indicating inefficient viral replication in the SARS-CoV-2-infected placenta. Additional studies are required to reveal the detailed mechanisms.

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