Linalool Impress Colorectal Cancer Deterioration by Mediating AKT/mTOR and JAK2/STAT3 Signaling Pathways

Colorectal cancer (CRC) is one of the more common causes of cancer death worldwide. Chemotherapy is effective in the treatment of CRC, but it can produce a range of adverse effects that can significantly reduce the quality of life of CRC patients. The selection of drugs that are effective in treatin...

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Autores principales: Hou, Min, Zhang, Yakun, Huang, Qingmei, Zhan, Hongmei, Jia, Tingting, Li, Min, Hu, Jing, Zhao, Yanli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293539/
https://www.ncbi.nlm.nih.gov/pubmed/35860797
http://dx.doi.org/10.1155/2022/4801703
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author Hou, Min
Zhang, Yakun
Huang, Qingmei
Zhan, Hongmei
Jia, Tingting
Li, Min
Hu, Jing
Zhao, Yanli
author_facet Hou, Min
Zhang, Yakun
Huang, Qingmei
Zhan, Hongmei
Jia, Tingting
Li, Min
Hu, Jing
Zhao, Yanli
author_sort Hou, Min
collection PubMed
description Colorectal cancer (CRC) is one of the more common causes of cancer death worldwide. Chemotherapy is effective in the treatment of CRC, but it can produce a range of adverse effects that can significantly reduce the quality of life of CRC patients. The selection of drugs that are effective in treating CRC with few adverse effects is now an important task and is aimed at prolonging the survival of patients and improving their prognosis. In this study, CRC cells were treated with linalool using CRC cell lines as the study subjects, and cell viability, apoptosis, and cell migration were observed after treatment. Previous studies have demonstrated the therapeutic effects of linalool on CRC and its ability to inhibit CRC progression by modulating the AKT/mTOR and JAK2/STAT3 pathways.
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spelling pubmed-92935392022-07-19 Linalool Impress Colorectal Cancer Deterioration by Mediating AKT/mTOR and JAK2/STAT3 Signaling Pathways Hou, Min Zhang, Yakun Huang, Qingmei Zhan, Hongmei Jia, Tingting Li, Min Hu, Jing Zhao, Yanli Biomed Res Int Research Article Colorectal cancer (CRC) is one of the more common causes of cancer death worldwide. Chemotherapy is effective in the treatment of CRC, but it can produce a range of adverse effects that can significantly reduce the quality of life of CRC patients. The selection of drugs that are effective in treating CRC with few adverse effects is now an important task and is aimed at prolonging the survival of patients and improving their prognosis. In this study, CRC cells were treated with linalool using CRC cell lines as the study subjects, and cell viability, apoptosis, and cell migration were observed after treatment. Previous studies have demonstrated the therapeutic effects of linalool on CRC and its ability to inhibit CRC progression by modulating the AKT/mTOR and JAK2/STAT3 pathways. Hindawi 2022-07-11 /pmc/articles/PMC9293539/ /pubmed/35860797 http://dx.doi.org/10.1155/2022/4801703 Text en Copyright © 2022 Min Hou et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hou, Min
Zhang, Yakun
Huang, Qingmei
Zhan, Hongmei
Jia, Tingting
Li, Min
Hu, Jing
Zhao, Yanli
Linalool Impress Colorectal Cancer Deterioration by Mediating AKT/mTOR and JAK2/STAT3 Signaling Pathways
title Linalool Impress Colorectal Cancer Deterioration by Mediating AKT/mTOR and JAK2/STAT3 Signaling Pathways
title_full Linalool Impress Colorectal Cancer Deterioration by Mediating AKT/mTOR and JAK2/STAT3 Signaling Pathways
title_fullStr Linalool Impress Colorectal Cancer Deterioration by Mediating AKT/mTOR and JAK2/STAT3 Signaling Pathways
title_full_unstemmed Linalool Impress Colorectal Cancer Deterioration by Mediating AKT/mTOR and JAK2/STAT3 Signaling Pathways
title_short Linalool Impress Colorectal Cancer Deterioration by Mediating AKT/mTOR and JAK2/STAT3 Signaling Pathways
title_sort linalool impress colorectal cancer deterioration by mediating akt/mtor and jak2/stat3 signaling pathways
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293539/
https://www.ncbi.nlm.nih.gov/pubmed/35860797
http://dx.doi.org/10.1155/2022/4801703
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