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Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40

The evolution of multidrug resistance in Acinetobacter spp. increases the risk of our best antibiotics losing their efficacy. From a clinical perspective, the carbapenem-hydrolyzing class D β-lactamase subfamily present in Acinetobacter spp. is particularly concerning because of its ability to confe...

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Detalles Bibliográficos
Autores principales:	Mitchell, Joshua M., June, Cynthia M., Baggett, Vincent L., Lowe, Beth C., Ruble, James F., Bonomo, Robert A., Leonard, David A., Powers, Rachel A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293634/ https://www.ncbi.nlm.nih.gov/pubmed/35709986 http://dx.doi.org/10.1016/j.jbc.2022.102127

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