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Inhibition of MAP4K4 signaling initiates metabolic reprogramming to protect hepatocytes from lipotoxic damage

The primary hepatic consequence of obesity is non-alcoholic fatty liver disease (NAFLD), affecting about 25% of the global adult population. Non-alcoholic steatohepatitis (NASH) is a severe form of NAFLD characterized by liver lipid accumulation, inflammation, and hepatocyte ballooning, with a diffe...

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Detalles Bibliográficos
Autores principales:	Anand, Sumit Kumar, Caputo, Mara, Xia, Ying, Andersson, Emma, Cansby, Emmelie, Kumari, Sima, Henricsson, Marcus, Porosk, Rando, Keuenhof, Katharina Susanne, Höög, Johanna Louise, Nair, Syam, Marschall, Hanns-Ulrich, Blüher, Matthias, Mahlapuu, Margit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293639/ https://www.ncbi.nlm.nih.gov/pubmed/35679904 http://dx.doi.org/10.1016/j.jlr.2022.100238

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