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Progress on carbon dots and hydroxyapatite based biocompatible luminescent nanomaterials for cancer theranostics
Despite the significant advancement in cancer diagnosis and therapy, a huge burden remains. Consequently, much research has been diverted on the development of multifunctional nanomaterials for improvement in conventional diagnosis and therapy. Luminescent nanomaterials offer a versatile platform fo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Neoplasia Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293661/ https://www.ncbi.nlm.nih.gov/pubmed/35841822 http://dx.doi.org/10.1016/j.tranon.2022.101482 |
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author | Sengar, Prakhar Chauhan, Kanchan Hirata, Gustavo A. |
author_facet | Sengar, Prakhar Chauhan, Kanchan Hirata, Gustavo A. |
author_sort | Sengar, Prakhar |
collection | PubMed |
description | Despite the significant advancement in cancer diagnosis and therapy, a huge burden remains. Consequently, much research has been diverted on the development of multifunctional nanomaterials for improvement in conventional diagnosis and therapy. Luminescent nanomaterials offer a versatile platform for the development of such materials as their intrinsic photoluminescence (PL) property offers convergence of diagnosis as well as therapy at the same time. However, the clinical translation of nanomaterials faces various challenges, including biocompatibility and cost-effective scale up production. Thus, luminescent materials with facile synthesis approach along with intrinsic biocompatibility and anticancerous activity hold significant importance. As a result, carbon dots (CDs) and nanohydroxyapatite (nHA) have attracted much attention for the development of optical imaging probes. CDs are the newest members of the carbonaceous nanomaterials family that possess intrinsic luminescent and therapeutic properties, making them a promising candidate for cancer theranostic. Additionally, nHA is an excellent bioactive material due to its compositional similarity to the human bone matrix. The nHA crystal can efficiently host rare-earth elements to attain luminescent property, which can further be implemented for cancer theranostic applications. Herein, the development of CDs and nHA based nanomaterials as multifunctional agents for cancer has been briefly discussed. The emphasis has been given to different synthesis strategies leading to different morphologies and tunable PL spectra, followed by their diverse applications as biocompatible theranostic agents. Finally, the review has been summarized with the current challenges and future perspectives. |
format | Online Article Text |
id | pubmed-9293661 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Neoplasia Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-92936612022-07-25 Progress on carbon dots and hydroxyapatite based biocompatible luminescent nanomaterials for cancer theranostics Sengar, Prakhar Chauhan, Kanchan Hirata, Gustavo A. Transl Oncol Commentary Despite the significant advancement in cancer diagnosis and therapy, a huge burden remains. Consequently, much research has been diverted on the development of multifunctional nanomaterials for improvement in conventional diagnosis and therapy. Luminescent nanomaterials offer a versatile platform for the development of such materials as their intrinsic photoluminescence (PL) property offers convergence of diagnosis as well as therapy at the same time. However, the clinical translation of nanomaterials faces various challenges, including biocompatibility and cost-effective scale up production. Thus, luminescent materials with facile synthesis approach along with intrinsic biocompatibility and anticancerous activity hold significant importance. As a result, carbon dots (CDs) and nanohydroxyapatite (nHA) have attracted much attention for the development of optical imaging probes. CDs are the newest members of the carbonaceous nanomaterials family that possess intrinsic luminescent and therapeutic properties, making them a promising candidate for cancer theranostic. Additionally, nHA is an excellent bioactive material due to its compositional similarity to the human bone matrix. The nHA crystal can efficiently host rare-earth elements to attain luminescent property, which can further be implemented for cancer theranostic applications. Herein, the development of CDs and nHA based nanomaterials as multifunctional agents for cancer has been briefly discussed. The emphasis has been given to different synthesis strategies leading to different morphologies and tunable PL spectra, followed by their diverse applications as biocompatible theranostic agents. Finally, the review has been summarized with the current challenges and future perspectives. Neoplasia Press 2022-07-13 /pmc/articles/PMC9293661/ /pubmed/35841822 http://dx.doi.org/10.1016/j.tranon.2022.101482 Text en © 2022 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Commentary Sengar, Prakhar Chauhan, Kanchan Hirata, Gustavo A. Progress on carbon dots and hydroxyapatite based biocompatible luminescent nanomaterials for cancer theranostics |
title | Progress on carbon dots and hydroxyapatite based biocompatible luminescent nanomaterials for cancer theranostics |
title_full | Progress on carbon dots and hydroxyapatite based biocompatible luminescent nanomaterials for cancer theranostics |
title_fullStr | Progress on carbon dots and hydroxyapatite based biocompatible luminescent nanomaterials for cancer theranostics |
title_full_unstemmed | Progress on carbon dots and hydroxyapatite based biocompatible luminescent nanomaterials for cancer theranostics |
title_short | Progress on carbon dots and hydroxyapatite based biocompatible luminescent nanomaterials for cancer theranostics |
title_sort | progress on carbon dots and hydroxyapatite based biocompatible luminescent nanomaterials for cancer theranostics |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293661/ https://www.ncbi.nlm.nih.gov/pubmed/35841822 http://dx.doi.org/10.1016/j.tranon.2022.101482 |
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