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Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer

Gastric cancer is one of the first malignant cancers in the world and a large number of people die every year due to this disease. Many genetic and epigenetic risk factors have been identified that play a major role in gastric cancer. HOTAIR is an effective epigenetic agent known as long noncoding R...

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Autores principales: Kong, Wencheng, Yin, Guang, Zheng, Sixin, Liu, Xinchun, Zhu, Akao, Yu, Panpan, Zhang, Jian, Shan, Yuqiang, Ying, Rongchao, Jin, Huicheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293693/
https://www.ncbi.nlm.nih.gov/pubmed/35873034
http://dx.doi.org/10.1016/j.gendis.2021.07.006
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author Kong, Wencheng
Yin, Guang
Zheng, Sixin
Liu, Xinchun
Zhu, Akao
Yu, Panpan
Zhang, Jian
Shan, Yuqiang
Ying, Rongchao
Jin, Huicheng
author_facet Kong, Wencheng
Yin, Guang
Zheng, Sixin
Liu, Xinchun
Zhu, Akao
Yu, Panpan
Zhang, Jian
Shan, Yuqiang
Ying, Rongchao
Jin, Huicheng
author_sort Kong, Wencheng
collection PubMed
description Gastric cancer is one of the first malignant cancers in the world and a large number of people die every year due to this disease. Many genetic and epigenetic risk factors have been identified that play a major role in gastric cancer. HOTAIR is an effective epigenetic agent known as long noncoding RNA (lncRNA). HOTAIR has been described to have biological functions in biochemical and cellular processes through interactions with many factors, leading to genomic stability, proliferation, survival, invasion, migration, metastasis, and drug resistance. In the present article, we reviewed the prognostic value of the molecular mechanisms underlying the HOTAIR regulation and its function in the development of Gastric Cancer, whereas elucidation of HOTAIR–protein and HOTAIR–DNA interactions can be helpful in the identification of cancer processes, leading to the development of potential therapeutic strategies.
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spelling pubmed-92936932022-07-21 Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer Kong, Wencheng Yin, Guang Zheng, Sixin Liu, Xinchun Zhu, Akao Yu, Panpan Zhang, Jian Shan, Yuqiang Ying, Rongchao Jin, Huicheng Genes Dis Review Article Gastric cancer is one of the first malignant cancers in the world and a large number of people die every year due to this disease. Many genetic and epigenetic risk factors have been identified that play a major role in gastric cancer. HOTAIR is an effective epigenetic agent known as long noncoding RNA (lncRNA). HOTAIR has been described to have biological functions in biochemical and cellular processes through interactions with many factors, leading to genomic stability, proliferation, survival, invasion, migration, metastasis, and drug resistance. In the present article, we reviewed the prognostic value of the molecular mechanisms underlying the HOTAIR regulation and its function in the development of Gastric Cancer, whereas elucidation of HOTAIR–protein and HOTAIR–DNA interactions can be helpful in the identification of cancer processes, leading to the development of potential therapeutic strategies. Chongqing Medical University 2021-08-21 /pmc/articles/PMC9293693/ /pubmed/35873034 http://dx.doi.org/10.1016/j.gendis.2021.07.006 Text en © 2021 Chongqing Medical University. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Kong, Wencheng
Yin, Guang
Zheng, Sixin
Liu, Xinchun
Zhu, Akao
Yu, Panpan
Zhang, Jian
Shan, Yuqiang
Ying, Rongchao
Jin, Huicheng
Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer
title Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer
title_full Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer
title_fullStr Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer
title_full_unstemmed Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer
title_short Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer
title_sort long noncoding rna (lncrna) hotair: pathogenic roles and therapeutic opportunities in gastric cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293693/
https://www.ncbi.nlm.nih.gov/pubmed/35873034
http://dx.doi.org/10.1016/j.gendis.2021.07.006
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