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Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer
Gastric cancer is one of the first malignant cancers in the world and a large number of people die every year due to this disease. Many genetic and epigenetic risk factors have been identified that play a major role in gastric cancer. HOTAIR is an effective epigenetic agent known as long noncoding R...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chongqing Medical University
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293693/ https://www.ncbi.nlm.nih.gov/pubmed/35873034 http://dx.doi.org/10.1016/j.gendis.2021.07.006 |
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author | Kong, Wencheng Yin, Guang Zheng, Sixin Liu, Xinchun Zhu, Akao Yu, Panpan Zhang, Jian Shan, Yuqiang Ying, Rongchao Jin, Huicheng |
author_facet | Kong, Wencheng Yin, Guang Zheng, Sixin Liu, Xinchun Zhu, Akao Yu, Panpan Zhang, Jian Shan, Yuqiang Ying, Rongchao Jin, Huicheng |
author_sort | Kong, Wencheng |
collection | PubMed |
description | Gastric cancer is one of the first malignant cancers in the world and a large number of people die every year due to this disease. Many genetic and epigenetic risk factors have been identified that play a major role in gastric cancer. HOTAIR is an effective epigenetic agent known as long noncoding RNA (lncRNA). HOTAIR has been described to have biological functions in biochemical and cellular processes through interactions with many factors, leading to genomic stability, proliferation, survival, invasion, migration, metastasis, and drug resistance. In the present article, we reviewed the prognostic value of the molecular mechanisms underlying the HOTAIR regulation and its function in the development of Gastric Cancer, whereas elucidation of HOTAIR–protein and HOTAIR–DNA interactions can be helpful in the identification of cancer processes, leading to the development of potential therapeutic strategies. |
format | Online Article Text |
id | pubmed-9293693 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Chongqing Medical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-92936932022-07-21 Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer Kong, Wencheng Yin, Guang Zheng, Sixin Liu, Xinchun Zhu, Akao Yu, Panpan Zhang, Jian Shan, Yuqiang Ying, Rongchao Jin, Huicheng Genes Dis Review Article Gastric cancer is one of the first malignant cancers in the world and a large number of people die every year due to this disease. Many genetic and epigenetic risk factors have been identified that play a major role in gastric cancer. HOTAIR is an effective epigenetic agent known as long noncoding RNA (lncRNA). HOTAIR has been described to have biological functions in biochemical and cellular processes through interactions with many factors, leading to genomic stability, proliferation, survival, invasion, migration, metastasis, and drug resistance. In the present article, we reviewed the prognostic value of the molecular mechanisms underlying the HOTAIR regulation and its function in the development of Gastric Cancer, whereas elucidation of HOTAIR–protein and HOTAIR–DNA interactions can be helpful in the identification of cancer processes, leading to the development of potential therapeutic strategies. Chongqing Medical University 2021-08-21 /pmc/articles/PMC9293693/ /pubmed/35873034 http://dx.doi.org/10.1016/j.gendis.2021.07.006 Text en © 2021 Chongqing Medical University. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Kong, Wencheng Yin, Guang Zheng, Sixin Liu, Xinchun Zhu, Akao Yu, Panpan Zhang, Jian Shan, Yuqiang Ying, Rongchao Jin, Huicheng Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer |
title | Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer |
title_full | Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer |
title_fullStr | Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer |
title_full_unstemmed | Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer |
title_short | Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer |
title_sort | long noncoding rna (lncrna) hotair: pathogenic roles and therapeutic opportunities in gastric cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293693/ https://www.ncbi.nlm.nih.gov/pubmed/35873034 http://dx.doi.org/10.1016/j.gendis.2021.07.006 |
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