Screening potential P-glycoprotein inhibitors by combination of a detergent-free membrane protein extraction with surface plasmon resonance biosensor

P-glycoprotein (P-gp) highly expressed in cancer cells can lead to multidrug resistance (MDR) and the combination of anti-cancer drugs with P-gp inhibitor has been a promising strategy to reverse MDR in cancer treatment. In this study, we established a label-free and detergent-free system combining...

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Detalles Bibliográficos
Autores principales: Cao, Yuhong, Fang, Jiahao, Shi, Yiwei, Wang, Hui, Chen, Xiaofei, Liu, Yue, Zhu, Zhenyu, Cao, Yan, Hong, Zhanying, Chai, Yifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293711/
https://www.ncbi.nlm.nih.gov/pubmed/35865104
http://dx.doi.org/10.1016/j.apsb.2022.03.016

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