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Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases

Macrophages are dominant innate immune cells. They demonstrate remarkable heterogeneity and plasticity that are essential for homeostasis and host defense. The heterogeneity of tissue macrophages is shaped by the ontogeny, tissue factors, and environmental signals, a pattern in a tissue-associated l...

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Autores principales: He, XiaoYi, Tan, Stephanie, Shao, Zhong, Wang, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293718/
https://www.ncbi.nlm.nih.gov/pubmed/35873033
http://dx.doi.org/10.1016/j.gendis.2021.06.007
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author He, XiaoYi
Tan, Stephanie
Shao, Zhong
Wang, Xiao
author_facet He, XiaoYi
Tan, Stephanie
Shao, Zhong
Wang, Xiao
author_sort He, XiaoYi
collection PubMed
description Macrophages are dominant innate immune cells. They demonstrate remarkable heterogeneity and plasticity that are essential for homeostasis and host defense. The heterogeneity of tissue macrophages is shaped by the ontogeny, tissue factors, and environmental signals, a pattern in a tissue-associated latitudinal manner. At the same time, macrophages have long been considered as mainly plastic cells. These cells respond to stimulation quickly and in a stimulus-specific way by utilizing a longitudinal cascaded activation, including coordination of signal transducer, epigenetic elements, and transcription factors, conclusively determine the macrophage phenotypes and functions. With the development of cutting-edge technologies, such as fate-mapping, single-cell transcriptomics, ipsc platform, nanotherapeutic materials, etc., our understanding of macrophage biology and the roles in the pathogenesis of diseases is much advanced. This review summarizes recent progress on the latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases. The latitudinal regulation covers the tissue macrophage origins, tissue factors, and environmental signals, reflecting the macrophage heterogeneity. The longitudinal regulation focuses on how multiple factors shape the phenotypes and functions of macrophage subsets to gain plasticity in inflammatory diseases (i.e., inflammatory bowel disease). In addition, how to target macrophages as a potential therapeutic approach and cutting edge-technologies for tissue macrophage study are also discussed in this review.
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spelling pubmed-92937182022-07-21 Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases He, XiaoYi Tan, Stephanie Shao, Zhong Wang, Xiao Genes Dis Review Article Macrophages are dominant innate immune cells. They demonstrate remarkable heterogeneity and plasticity that are essential for homeostasis and host defense. The heterogeneity of tissue macrophages is shaped by the ontogeny, tissue factors, and environmental signals, a pattern in a tissue-associated latitudinal manner. At the same time, macrophages have long been considered as mainly plastic cells. These cells respond to stimulation quickly and in a stimulus-specific way by utilizing a longitudinal cascaded activation, including coordination of signal transducer, epigenetic elements, and transcription factors, conclusively determine the macrophage phenotypes and functions. With the development of cutting-edge technologies, such as fate-mapping, single-cell transcriptomics, ipsc platform, nanotherapeutic materials, etc., our understanding of macrophage biology and the roles in the pathogenesis of diseases is much advanced. This review summarizes recent progress on the latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases. The latitudinal regulation covers the tissue macrophage origins, tissue factors, and environmental signals, reflecting the macrophage heterogeneity. The longitudinal regulation focuses on how multiple factors shape the phenotypes and functions of macrophage subsets to gain plasticity in inflammatory diseases (i.e., inflammatory bowel disease). In addition, how to target macrophages as a potential therapeutic approach and cutting edge-technologies for tissue macrophage study are also discussed in this review. Chongqing Medical University 2021-07-13 /pmc/articles/PMC9293718/ /pubmed/35873033 http://dx.doi.org/10.1016/j.gendis.2021.06.007 Text en © 2021 Chongqing Medical University. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
He, XiaoYi
Tan, Stephanie
Shao, Zhong
Wang, Xiao
Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases
title Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases
title_full Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases
title_fullStr Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases
title_full_unstemmed Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases
title_short Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases
title_sort latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293718/
https://www.ncbi.nlm.nih.gov/pubmed/35873033
http://dx.doi.org/10.1016/j.gendis.2021.06.007
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