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Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases
Macrophages are dominant innate immune cells. They demonstrate remarkable heterogeneity and plasticity that are essential for homeostasis and host defense. The heterogeneity of tissue macrophages is shaped by the ontogeny, tissue factors, and environmental signals, a pattern in a tissue-associated l...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chongqing Medical University
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293718/ https://www.ncbi.nlm.nih.gov/pubmed/35873033 http://dx.doi.org/10.1016/j.gendis.2021.06.007 |
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author | He, XiaoYi Tan, Stephanie Shao, Zhong Wang, Xiao |
author_facet | He, XiaoYi Tan, Stephanie Shao, Zhong Wang, Xiao |
author_sort | He, XiaoYi |
collection | PubMed |
description | Macrophages are dominant innate immune cells. They demonstrate remarkable heterogeneity and plasticity that are essential for homeostasis and host defense. The heterogeneity of tissue macrophages is shaped by the ontogeny, tissue factors, and environmental signals, a pattern in a tissue-associated latitudinal manner. At the same time, macrophages have long been considered as mainly plastic cells. These cells respond to stimulation quickly and in a stimulus-specific way by utilizing a longitudinal cascaded activation, including coordination of signal transducer, epigenetic elements, and transcription factors, conclusively determine the macrophage phenotypes and functions. With the development of cutting-edge technologies, such as fate-mapping, single-cell transcriptomics, ipsc platform, nanotherapeutic materials, etc., our understanding of macrophage biology and the roles in the pathogenesis of diseases is much advanced. This review summarizes recent progress on the latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases. The latitudinal regulation covers the tissue macrophage origins, tissue factors, and environmental signals, reflecting the macrophage heterogeneity. The longitudinal regulation focuses on how multiple factors shape the phenotypes and functions of macrophage subsets to gain plasticity in inflammatory diseases (i.e., inflammatory bowel disease). In addition, how to target macrophages as a potential therapeutic approach and cutting edge-technologies for tissue macrophage study are also discussed in this review. |
format | Online Article Text |
id | pubmed-9293718 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Chongqing Medical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-92937182022-07-21 Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases He, XiaoYi Tan, Stephanie Shao, Zhong Wang, Xiao Genes Dis Review Article Macrophages are dominant innate immune cells. They demonstrate remarkable heterogeneity and plasticity that are essential for homeostasis and host defense. The heterogeneity of tissue macrophages is shaped by the ontogeny, tissue factors, and environmental signals, a pattern in a tissue-associated latitudinal manner. At the same time, macrophages have long been considered as mainly plastic cells. These cells respond to stimulation quickly and in a stimulus-specific way by utilizing a longitudinal cascaded activation, including coordination of signal transducer, epigenetic elements, and transcription factors, conclusively determine the macrophage phenotypes and functions. With the development of cutting-edge technologies, such as fate-mapping, single-cell transcriptomics, ipsc platform, nanotherapeutic materials, etc., our understanding of macrophage biology and the roles in the pathogenesis of diseases is much advanced. This review summarizes recent progress on the latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases. The latitudinal regulation covers the tissue macrophage origins, tissue factors, and environmental signals, reflecting the macrophage heterogeneity. The longitudinal regulation focuses on how multiple factors shape the phenotypes and functions of macrophage subsets to gain plasticity in inflammatory diseases (i.e., inflammatory bowel disease). In addition, how to target macrophages as a potential therapeutic approach and cutting edge-technologies for tissue macrophage study are also discussed in this review. Chongqing Medical University 2021-07-13 /pmc/articles/PMC9293718/ /pubmed/35873033 http://dx.doi.org/10.1016/j.gendis.2021.06.007 Text en © 2021 Chongqing Medical University. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article He, XiaoYi Tan, Stephanie Shao, Zhong Wang, Xiao Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases |
title | Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases |
title_full | Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases |
title_fullStr | Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases |
title_full_unstemmed | Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases |
title_short | Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases |
title_sort | latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293718/ https://www.ncbi.nlm.nih.gov/pubmed/35873033 http://dx.doi.org/10.1016/j.gendis.2021.06.007 |
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