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Serum protein and electrolyte imbalances are associated with chemotherapy induced neutropenia

INTRODUCTION: Cancer and its treatment using various chemotherapeutic agents can have many adverse side effects. These side effects often result in significant changes in haematological and biochemical composition of blood. As a result, the regular monitoring of serum biochemical and haematological...

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Autores principales: Abbasi, Benazir, Hayat, Amjad, Lyons, Mark, Gupta, Ananya, Gupta, Sanjeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293742/
https://www.ncbi.nlm.nih.gov/pubmed/35865973
http://dx.doi.org/10.1016/j.heliyon.2022.e09949
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author Abbasi, Benazir
Hayat, Amjad
Lyons, Mark
Gupta, Ananya
Gupta, Sanjeev
author_facet Abbasi, Benazir
Hayat, Amjad
Lyons, Mark
Gupta, Ananya
Gupta, Sanjeev
author_sort Abbasi, Benazir
collection PubMed
description INTRODUCTION: Cancer and its treatment using various chemotherapeutic agents can have many adverse side effects. These side effects often result in significant changes in haematological and biochemical composition of blood. As a result, the regular monitoring of serum biochemical and haematological changes plays an important role in management of disease. The present study aimed to determine the relationship between haematological and biochemical changes in neutropenic cancer patients following chemotherapy. Specifically we evaluated the association between neutrophil count and serum proteins and electrolytes. METHODS: For this purpose we analysed retrospectively collected laboratory results from two independent patient cohorts. Each cohort was divided into a control group consisting of patients with normal haematological parameters and a study group which included patients with reduced neutrophil counts. Neutropenic patients (study group) were cancer patients on chemotherapy. RESULTS AND CONCLUSION: Blood samples of cancer patients in study group showed reduction in haemoglobin, neutrophils and platelets. Neutropenic group showed a significant reduction in serum albumin, total protein, calcium, and potassium. Our results show that patients with severe neutropenia had pronounced changes in serum protein and electrolytes and increased incidence of abnormal serum protein and electrolyte level. The changes in the neutrophil counts showed a positive correlation with the changes in serum protein and electrolyte levels. A similar trend was seen in both the patient cohorts: the discovery set (176 patients) and the validation set (200 patients). Taken together our results suggest that chemotherapy-induced neutropenia is associated with dysregulation in haemoglobin, platelets, serum proteins and electrolytes.
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spelling pubmed-92937422022-07-20 Serum protein and electrolyte imbalances are associated with chemotherapy induced neutropenia Abbasi, Benazir Hayat, Amjad Lyons, Mark Gupta, Ananya Gupta, Sanjeev Heliyon Research Article INTRODUCTION: Cancer and its treatment using various chemotherapeutic agents can have many adverse side effects. These side effects often result in significant changes in haematological and biochemical composition of blood. As a result, the regular monitoring of serum biochemical and haematological changes plays an important role in management of disease. The present study aimed to determine the relationship between haematological and biochemical changes in neutropenic cancer patients following chemotherapy. Specifically we evaluated the association between neutrophil count and serum proteins and electrolytes. METHODS: For this purpose we analysed retrospectively collected laboratory results from two independent patient cohorts. Each cohort was divided into a control group consisting of patients with normal haematological parameters and a study group which included patients with reduced neutrophil counts. Neutropenic patients (study group) were cancer patients on chemotherapy. RESULTS AND CONCLUSION: Blood samples of cancer patients in study group showed reduction in haemoglobin, neutrophils and platelets. Neutropenic group showed a significant reduction in serum albumin, total protein, calcium, and potassium. Our results show that patients with severe neutropenia had pronounced changes in serum protein and electrolytes and increased incidence of abnormal serum protein and electrolyte level. The changes in the neutrophil counts showed a positive correlation with the changes in serum protein and electrolyte levels. A similar trend was seen in both the patient cohorts: the discovery set (176 patients) and the validation set (200 patients). Taken together our results suggest that chemotherapy-induced neutropenia is associated with dysregulation in haemoglobin, platelets, serum proteins and electrolytes. Elsevier 2022-07-12 /pmc/articles/PMC9293742/ /pubmed/35865973 http://dx.doi.org/10.1016/j.heliyon.2022.e09949 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Abbasi, Benazir
Hayat, Amjad
Lyons, Mark
Gupta, Ananya
Gupta, Sanjeev
Serum protein and electrolyte imbalances are associated with chemotherapy induced neutropenia
title Serum protein and electrolyte imbalances are associated with chemotherapy induced neutropenia
title_full Serum protein and electrolyte imbalances are associated with chemotherapy induced neutropenia
title_fullStr Serum protein and electrolyte imbalances are associated with chemotherapy induced neutropenia
title_full_unstemmed Serum protein and electrolyte imbalances are associated with chemotherapy induced neutropenia
title_short Serum protein and electrolyte imbalances are associated with chemotherapy induced neutropenia
title_sort serum protein and electrolyte imbalances are associated with chemotherapy induced neutropenia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293742/
https://www.ncbi.nlm.nih.gov/pubmed/35865973
http://dx.doi.org/10.1016/j.heliyon.2022.e09949
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