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Characterizing unexpected interactions of a glutamine transporter inhibitor with members of the SLC1A transporter family

The solute carrier 1A family comprises a group of membrane proteins that act as dual-function amino acid transporters and chloride (Cl(−)) channels and includes the alanine serine cysteine transporters (ASCTs) as well as the excitatory amino acid transporters. ASCT2 is regarded as a promising target...

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Detalles Bibliográficos
Autores principales: Freidman, Natasha J., Briot, Chelsea, Ryan, Renae M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293768/
https://www.ncbi.nlm.nih.gov/pubmed/35752361
http://dx.doi.org/10.1016/j.jbc.2022.102178