Expression of a novel mycobacterial phosphodiesterase successfully lowers cAMP levels resulting in reduced tolerance to cell wall–targeting antimicrobials

cAMP and antimicrobial susceptibility in mycobacteriaAntimicrobial tolerance, the ability to survive exposure to antimicrobials via transient nonspecific means, promotes the development of antimicrobial resistance (AMR). The study of the molecular mechanisms that result in antimicrobial tolerance is...

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Detalles Bibliográficos
Autores principales: Thomson, Michael, Liu, Yi, Nunta, Kanokkan, Cheyne, Ashleigh, Fernandes, Nadia, Williams, Richard, Garza-Garcia, Acely, Larrouy-Maumus, Gerald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293780/
https://www.ncbi.nlm.nih.gov/pubmed/35718063
http://dx.doi.org/10.1016/j.jbc.2022.102151

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