Casein kinase 1δ/ε phosphorylates fused in sarcoma (FUS) and ameliorates FUS-mediated neurodegeneration

Aberrant cytoplasmic accumulation of an RNA-binding protein, fused in sarcoma (FUS), characterizes the neuropathology of subtypes of ALS and frontotemporal lobar degeneration, although the effects of post-translational modifications of FUS, especially phosphorylation, on its neurotoxicity have not b...

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Detalles Bibliográficos
Autores principales: Kishino, Yuya, Matsukawa, Koji, Matsumoto, Taisei, Miyazaki, Ryota, Wakabayashi, Tomoko, Nonaka, Takashi, Kametani, Fuyuki, Hasegawa, Masato, Hashimoto, Tadafumi, Iwatsubo, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293781/
https://www.ncbi.nlm.nih.gov/pubmed/35753345
http://dx.doi.org/10.1016/j.jbc.2022.102191

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