Characterization of a cotton-wool like composite bone graft material

Bone graft materials are applied in patients to augment bone defects and enable the insertion of an implant in its ideal position. However, the currently available augmentation materials do not meet the requirements of being completely resorbed and replaced by new bone within 3 to 6 months. A novel...

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Autores principales: Rohr, Nadja, Brunner, Claudia, Bellon, Benjamin, Fischer, Jens, de Wild, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Biomaterials Synthesis and Characterization
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293850/
https://www.ncbi.nlm.nih.gov/pubmed/35849225
http://dx.doi.org/10.1007/s10856-022-06682-3
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author Rohr, Nadja
Brunner, Claudia
Bellon, Benjamin
Fischer, Jens
de Wild, Michael
author_facet Rohr, Nadja
Brunner, Claudia
Bellon, Benjamin
Fischer, Jens
de Wild, Michael
author_sort Rohr, Nadja
collection PubMed
description Bone graft materials are applied in patients to augment bone defects and enable the insertion of an implant in its ideal position. However, the currently available augmentation materials do not meet the requirements of being completely resorbed and replaced by new bone within 3 to 6 months. A novel electrospun cotton-wool like material (Bonewool(®), Zurich Biomaterials LLC, Zurich, Switzerland) consisting of biodegradable poly(lactic-co-glycolic) acid (PLGA) fibers with incorporated amorphous ß-tricalcium phosphate (ß-TCP) nanoparticles has been compared to a frequently used bovine derived hydroxyapatite (Bio-Oss(®), Geistlich Pharma, Wolhusen, Switzerland) in vitro. The material composition was determined and the degradation behavior (calcium release and pH in different solutions) as well as bioactivity has been measured. Degradation behavior of PLGA/ß-TCP was generally more progressive than for Bio-Oss(®), indicating that this material is potentially completely resorbable. [Figure: see text]
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spelling pubmed-92938502022-07-20 Characterization of a cotton-wool like composite bone graft material Rohr, Nadja Brunner, Claudia Bellon, Benjamin Fischer, Jens de Wild, Michael J Mater Sci Mater Med Biomaterials Synthesis and Characterization Bone graft materials are applied in patients to augment bone defects and enable the insertion of an implant in its ideal position. However, the currently available augmentation materials do not meet the requirements of being completely resorbed and replaced by new bone within 3 to 6 months. A novel electrospun cotton-wool like material (Bonewool(®), Zurich Biomaterials LLC, Zurich, Switzerland) consisting of biodegradable poly(lactic-co-glycolic) acid (PLGA) fibers with incorporated amorphous ß-tricalcium phosphate (ß-TCP) nanoparticles has been compared to a frequently used bovine derived hydroxyapatite (Bio-Oss(®), Geistlich Pharma, Wolhusen, Switzerland) in vitro. The material composition was determined and the degradation behavior (calcium release and pH in different solutions) as well as bioactivity has been measured. Degradation behavior of PLGA/ß-TCP was generally more progressive than for Bio-Oss(®), indicating that this material is potentially completely resorbable. [Figure: see text] Springer US 2022-07-18 2022 /pmc/articles/PMC9293850/ /pubmed/35849225 http://dx.doi.org/10.1007/s10856-022-06682-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Biomaterials Synthesis and Characterization
Rohr, Nadja
Brunner, Claudia
Bellon, Benjamin
Fischer, Jens
de Wild, Michael
Characterization of a cotton-wool like composite bone graft material
title Characterization of a cotton-wool like composite bone graft material
title_full Characterization of a cotton-wool like composite bone graft material
title_fullStr Characterization of a cotton-wool like composite bone graft material
title_full_unstemmed Characterization of a cotton-wool like composite bone graft material
title_short Characterization of a cotton-wool like composite bone graft material
title_sort characterization of a cotton-wool like composite bone graft material
topic Biomaterials Synthesis and Characterization
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293850/
https://www.ncbi.nlm.nih.gov/pubmed/35849225
http://dx.doi.org/10.1007/s10856-022-06682-3
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AT fischerjens characterizationofacottonwoollikecompositebonegraftmaterial
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