Memantine treatment does not affect compulsive behavior or frontostriatal connectivity in an adolescent rat model for quinpirole-induced compulsive checking behavior

RATIONALE: Compulsivity often develops during childhood and is associated with elevated glutamate levels within the frontostriatal system. This suggests that anti-glutamatergic drugs, like memantine, may be an effective treatment. OBJECTIVE: Our goal was to characterize the acute and chronic effect...

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Detalles Bibliográficos
Autores principales: Straathof, Milou, Blezer, Erwin L. A., Smeele, Christel E., van Heijningen, Caroline, van der Toorn, Annette, Buitelaar, Jan K., Glennon, Jeffrey C., Otte, Willem M., Dijkhuizen, Rick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293859/
https://www.ncbi.nlm.nih.gov/pubmed/35419637
http://dx.doi.org/10.1007/s00213-022-06139-z

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