Selective activation of Gαob by an adenosine A(1) receptor agonist elicits analgesia without cardiorespiratory depression

The development of therapeutic agonists for G protein-coupled receptors (GPCRs) is hampered by the propensity of GPCRs to couple to multiple intracellular signalling pathways. This promiscuous coupling leads to numerous downstream cellular effects, some of which are therapeutically undesirable. This...

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Detalles Bibliográficos
Autores principales: Wall, Mark J., Hill, Emily, Huckstepp, Robert, Barkan, Kerry, Deganutti, Giuseppe, Leuenberger, Michele, Preti, Barbara, Winfield, Ian, Carvalho, Sabrina, Suchankova, Anna, Wei, Haifeng, Safitri, Dewi, Huang, Xianglin, Imlach, Wendy, La Mache, Circe, Dean, Eve, Hume, Cherise, Hayward, Stephanie, Oliver, Jess, Zhao, Fei-Yue, Spanswick, David, Reynolds, Christopher A., Lochner, Martin, Ladds, Graham, Frenguelli, Bruno G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293909/
https://www.ncbi.nlm.nih.gov/pubmed/35851064
http://dx.doi.org/10.1038/s41467-022-31652-2

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