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Critical structural elements for the antigenicity of wheat allergen LTP1 (Tri a 14) revealed by site-directed mutagenesis

Lipid transfer proteins (LTPs) were identified as allergens in a large variety of pollens and foods, including cereals. LTPs belong to the prolamin superfamily and display an α-helical fold, with a bundle of four α-helices held together by four disulfide bonds. Wheat LTP1 is involved in allergic rea...

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Detalles Bibliográficos
Autores principales: Mameri, Hamza, Gaudin, Jean-Charles, Lollier, Virginie, Tranquet, Olivier, Brossard, Chantal, Pietri, Manon, Marion, Didier, Codreanu-Morel, Fanny, Beaudouin, Etienne, Wien, Frank, Gohon, Yann, Briozzo, Pierre, Denery-Papini, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293932/
https://www.ncbi.nlm.nih.gov/pubmed/35851276
http://dx.doi.org/10.1038/s41598-022-15811-5