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Ameliorative effect of L-carnitine on lambda-cyhalothrin-induced anatomical and reproductive aberrations in albino mice

The objective of this research was to look at how the pesticide lambda-cyhalothrin (LCT) affected the liver, kidney, testis, and ovary of albino mice; and on morphological and skeletal features of the newborn of treated females. The study also aimed to test the ameliorative effects of L-carnitine (L...

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Autores principales: Al Malahi, Nawal M., Al Jumaily, Masaa M., Al-shaibani, Elham A.S., Alajmi, Reem A., Alkhuriji, Afrah F., Al-Tamimi, Jameel, Alhimaidi, Ahmad R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293953/
https://www.ncbi.nlm.nih.gov/pubmed/35865321
http://dx.doi.org/10.1016/j.sjbs.2022.103373
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author Al Malahi, Nawal M.
Al Jumaily, Masaa M.
Al-shaibani, Elham A.S.
Alajmi, Reem A.
Alkhuriji, Afrah F.
Al-Tamimi, Jameel
Alhimaidi, Ahmad R
author_facet Al Malahi, Nawal M.
Al Jumaily, Masaa M.
Al-shaibani, Elham A.S.
Alajmi, Reem A.
Alkhuriji, Afrah F.
Al-Tamimi, Jameel
Alhimaidi, Ahmad R
author_sort Al Malahi, Nawal M.
collection PubMed
description The objective of this research was to look at how the pesticide lambda-cyhalothrin (LCT) affected the liver, kidney, testis, and ovary of albino mice; and on morphological and skeletal features of the newborn of treated females. The study also aimed to test the ameliorative effects of L-carnitine (LC) against (LCT). Five sets of mice were created, Group 1 acted as the control, while Group 2 received a high dose of LCT, Group 3 received a high dose of LCT + LC, Group 4 received a low dose of LCT that was a residue of in khat (Qat), and Group 5 received a low dose of LCT + LC. The findings revealed that the treated groups' body weights were reduced significantly, whereas the absolute and relative weights of the liver in all groups were statistically decreased insignificantly. There were histopathological changes in the tissues in groups 2 and 4. While the tissues of the ovary and testis showed recovery in groups 3 and 5. When compared to the control group, the values of the seminiferous tubules parameters were statistically significant in the 3 and 5 groups. The newborn had a high dose of pesticides and showed some malformations in the skeleton. However, in group 3 the skeletal malformation was minimized and in-group 5 the skeleton malformations had completely disappeared. It could be concluded that LCT is highly harmful to mouse tissues and caused neonatal malformations, whereas LC has a marked protective effect against LCT.
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spelling pubmed-92939532022-07-20 Ameliorative effect of L-carnitine on lambda-cyhalothrin-induced anatomical and reproductive aberrations in albino mice Al Malahi, Nawal M. Al Jumaily, Masaa M. Al-shaibani, Elham A.S. Alajmi, Reem A. Alkhuriji, Afrah F. Al-Tamimi, Jameel Alhimaidi, Ahmad R Saudi J Biol Sci Original Article The objective of this research was to look at how the pesticide lambda-cyhalothrin (LCT) affected the liver, kidney, testis, and ovary of albino mice; and on morphological and skeletal features of the newborn of treated females. The study also aimed to test the ameliorative effects of L-carnitine (LC) against (LCT). Five sets of mice were created, Group 1 acted as the control, while Group 2 received a high dose of LCT, Group 3 received a high dose of LCT + LC, Group 4 received a low dose of LCT that was a residue of in khat (Qat), and Group 5 received a low dose of LCT + LC. The findings revealed that the treated groups' body weights were reduced significantly, whereas the absolute and relative weights of the liver in all groups were statistically decreased insignificantly. There were histopathological changes in the tissues in groups 2 and 4. While the tissues of the ovary and testis showed recovery in groups 3 and 5. When compared to the control group, the values of the seminiferous tubules parameters were statistically significant in the 3 and 5 groups. The newborn had a high dose of pesticides and showed some malformations in the skeleton. However, in group 3 the skeletal malformation was minimized and in-group 5 the skeleton malformations had completely disappeared. It could be concluded that LCT is highly harmful to mouse tissues and caused neonatal malformations, whereas LC has a marked protective effect against LCT. Elsevier 2022-09 2022-07-04 /pmc/articles/PMC9293953/ /pubmed/35865321 http://dx.doi.org/10.1016/j.sjbs.2022.103373 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Al Malahi, Nawal M.
Al Jumaily, Masaa M.
Al-shaibani, Elham A.S.
Alajmi, Reem A.
Alkhuriji, Afrah F.
Al-Tamimi, Jameel
Alhimaidi, Ahmad R
Ameliorative effect of L-carnitine on lambda-cyhalothrin-induced anatomical and reproductive aberrations in albino mice
title Ameliorative effect of L-carnitine on lambda-cyhalothrin-induced anatomical and reproductive aberrations in albino mice
title_full Ameliorative effect of L-carnitine on lambda-cyhalothrin-induced anatomical and reproductive aberrations in albino mice
title_fullStr Ameliorative effect of L-carnitine on lambda-cyhalothrin-induced anatomical and reproductive aberrations in albino mice
title_full_unstemmed Ameliorative effect of L-carnitine on lambda-cyhalothrin-induced anatomical and reproductive aberrations in albino mice
title_short Ameliorative effect of L-carnitine on lambda-cyhalothrin-induced anatomical and reproductive aberrations in albino mice
title_sort ameliorative effect of l-carnitine on lambda-cyhalothrin-induced anatomical and reproductive aberrations in albino mice
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293953/
https://www.ncbi.nlm.nih.gov/pubmed/35865321
http://dx.doi.org/10.1016/j.sjbs.2022.103373
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