Mitochondria dysfunction in Charcot Marie Tooth 2B Peripheral Sensory Neuropathy

Rab7 GTPase regulates mitochondrial morphology and function. Missense mutation(s) of Rab7 underlies the pathogenesis of Charcot Marie Tooth 2B (CMT2B) peripheral neuropathy. Herein, we investigate how mitochondrial morphology and function are impacted by the CMT2B associated Rab7(V162M) mutation. In...

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Detalles Bibliográficos
Autores principales: Gu, Yingli, Guerra, Flora, Hu, Mingzheng, Pope, Alexander, Sung, Kijung, Yang, Wanlin, Jetha, Simone, Shoff, Thomas A., Gunatilake, Tessanya, Dahlkamp, Owen, Shi, Linda Zhixia, Manganelli, Fiore, Nolano, Maria, Zhou, Yue, Ding, Jianqing, Bucci, Cecilia, Wu, Chengbiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293960/
https://www.ncbi.nlm.nih.gov/pubmed/35851620
http://dx.doi.org/10.1038/s42003-022-03632-1

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