Cargando…

A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer’s disease and gastrointestinal tract disorders

Consistent with the concept of the gut-brain phenomenon, observational studies suggest a relationship between Alzheimer’s disease (AD) and gastrointestinal tract (GIT) disorders; however, their underlying mechanisms remain unclear. Here, we analyse several genome-wide association studies (GWAS) summ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Adewuyi, Emmanuel O., O’Brien, Eleanor K., Nyholt, Dale R., Porter, Tenielle, Laws, Simon M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293965/ https://www.ncbi.nlm.nih.gov/pubmed/35851147 http://dx.doi.org/10.1038/s42003-022-03607-2

Ejemplares similares

Relationship of Cognition and Alzheimer’s Disease with Gastrointestinal Tract Disorders: A Large-Scale Genetic Overlap and Mendelian Randomisation Analysis
por: Adewuyi, Emmanuel O., et al.
Publicado: (2022)

A Potential Role for Sirtuin-1 in Alzheimer’s Disease: Reviewing the Biological and Environmental Evidence
por: Mehramiz, Mehrane, et al.
Publicado: (2023)

Utility of DNA Methylation as a Biomarker in Aging and Alzheimer’s Disease
por: Milicic, Lidija, et al.
Publicado: (2023)

Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity
por: Adewuyi, Emmanuel O., et al.
Publicado: (2020)

Sleep, Sirtuin 1 and Alzheimer’s disease: A review
por: Mehramiz, Mehrane, et al.
Publicado: (2022)

Cross-trait analyses identify shared genetics between migraine, headache, and glycemic traits, and a causal relationship with fasting proinsulin
por: Islam, Md Rafiqul, et al.
Publicado: (2023)

Genome-wide imputed differential expression enrichment analysis identifies trait-relevant tissues
por: Ghaffar, Ammarah, et al.
Publicado: (2023)

Current Insights on the Use of Insulin and the Potential Use of Insulin Mimetics in Targeting Insulin Signalling in Alzheimer’s Disease
por: Woodfield, Amy, et al.
Publicado: (2022)

Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture
por: Zhang, Qian, et al.
Publicado: (2020)

The shared genetic landscape of blood cell traits and risk of neurological and psychiatric disorders
por: Yang, Yuanhao, et al.
Publicado: (2023)

Shared genetic architecture of COVID-19 and Alzheimer’s disease
por: Matveeva, Natalia, et al.
Publicado: (2023)

Modular genome-wide gene expression architecture shared by early traits of osteoporosis and atherosclerosis in the Young Finns Study
por: Mishra, Binisha H., et al.
Publicado: (2021)

The shared genetic risk architecture of neurological and psychiatric disorders: a genome-wide analysis
por: Smeland, Olav B., et al.
Publicado: (2023)

Genetic Overlap Analysis Identifies a Shared Etiology between Migraine and Headache with Type 2 Diabetes
por: Islam, Md Rafiqul, et al.
Publicado: (2022)

Hair and salivary cortisol and their relationship with lifestyle, mood and cognitive outcomes in premanifest Huntington’s disease
por: Cruickshank, Travis, et al.
Publicado: (2021)

Glucose-Related Traits and Risk of Migraine—A Potential Mechanism and Treatment Consideration
por: Islam, Md Rafiqul, et al.
Publicado: (2022)

Comparative genomics and phenotypic studies to determine site-specificity of Escherichia coli in the lower gastrointestinal tract of humans
por: Barua, Rasel, et al.
Publicado: (2023)

The shared genetic architecture between epidemiological and behavioral traits with lung cancer
por: Pettit, Rowland W., et al.
Publicado: (2021)

Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits
por: Quach, Bryan C., et al.
Publicado: (2020)

A genome-wide cross trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases
por: Zhu, Zhaozhong, et al.
Publicado: (2018)

Cross-Trait Genetic Analyses Indicate Pleiotropy and Complex Causal Relationships between Headache and Thyroid Function Traits
por: Tasnim, Sana, et al.
Publicado: (2022)

Shared genetic influences between blood analyte levels and risk of severe COVID-19
por: Tanha, Hamzeh M., et al.
Publicado: (2022)

Sixteen-Year Longitudinal Evaluation of Blood-Based DNA Methylation Biomarkers for Early Prediction of Alzheimer’s Disease
por: Schäfer Hackenhaar, Fernanda, et al.
Publicado: (2023)

The Gastrointestinal Tract Microbiome and Potential Link to Alzheimer’s Disease
por: Hill, James M., et al.
Publicado: (2014)

Rare variants confer shared susceptibility to gastrointestinal tract cancer risk
por: Zheng, Ji, et al.
Publicado: (2023)

Assessing the presence of shared genetic architecture between Alzheimer's disease and major depressive disorder using genome-wide association data
por: Gibson, J, et al.
Publicado: (2017)

A genome-wide cross-trait analysis highlights the shared genetic structure between COVID-19 and Alzheimer's disease
por: Qiu, Shizheng, et al.
Publicado: (2021)

No decision about me without me? Shared decision-making in mental healthcare
por: O'Brien, Aileen
Publicado: (2022)

Assessment of a polygenic hazard score for the onset of pre-clinical Alzheimer’s disease
por: Vacher, Michael, et al.
Publicado: (2022)

Shared genetic architecture between the two neurodegenerative diseases: Alzheimer’s disease and glaucoma
por: Zheng, Chunwen, et al.
Publicado: (2022)

The Effects of Latrepirdine on Amyloid-β Aggregation and Toxicity
por: Porter, Tenielle, et al.
Publicado: (2016)

The Role of Cell Surface Architecture of Lactobacilli in Host-Microbe Interactions in the Gastrointestinal Tract
por: Sengupta, Ranjita, et al.
Publicado: (2013)

The shared genetic basis of mood instability and psychiatric disorders: A cross‐trait genome‐wide association analysis
por: Hindley, Guy, et al.
Publicado: (2022)

Validation of a priori candidate Alzheimer’s disease SNPs with brain amyloid-beta deposition
por: Vacher, Michael, et al.
Publicado: (2019)

Adhesion GPCRs are widely expressed throughout the subsections of the gastrointestinal tract
por: Badiali, Luca, et al.
Publicado: (2012)

The Genetic Architecture of Multiple Myeloma
por: Prideaux, Steven M., et al.
Publicado: (2014)

Role of the Gut-Brain Axis in the Shared Genetic Etiology Between Gastrointestinal Tract Diseases and Psychiatric Disorders: A Genome-Wide Pleiotropic Analysis
por: Gong, Weiming, et al.
Publicado: (2023)

Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci
por: Jaholkowski, Piotr, et al.
Publicado: (2023)

Hearing difficulty is linked to Alzheimer’s disease by common genetic vulnerability, not shared genetic architecture
por: Abidin, Fatin N. Zainul, et al.
Publicado: (2021)

Gastrointestinal Tract Microbiome-Derived Pro-inflammatory Neurotoxins in Alzheimer’s Disease
por: Zhao, Yuhai, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_imreshda3i7cs8ff4l4is718me