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An immunological autobiography: my year as a COVID-19 vaccine trial participant

After enrolling in the Moderna phase III clinical trial, I collected my own biological samples pre- and post-immunization in the event of being a recipient of the experimental vaccine. The evidence strongly supports the conclusion that I did not receive the placebo. The analysis is admittedly limite...

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Autor principal: Kedl, Ross M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293989/
https://www.ncbi.nlm.nih.gov/pubmed/35851389
http://dx.doi.org/10.1038/s41541-022-00502-z
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description After enrolling in the Moderna phase III clinical trial, I collected my own biological samples pre- and post-immunization in the event of being a recipient of the experimental vaccine. The evidence strongly supports the conclusion that I did not receive the placebo. The analysis is admittedly limited to an n of 1, but the results fit well with data taken from published works and represent one of the more comprehensive longitudinal evaluations of vaccine-elicited immunity within a single individual yet to be undertaken. Though the data amount to a well-documented anecdote, given its granularity, it is not without its insights and may be of further use in directing future longitudinal studies that have actual statistical significance.
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spelling pubmed-92939892022-07-19 An immunological autobiography: my year as a COVID-19 vaccine trial participant Kedl, Ross M. NPJ Vaccines Comment After enrolling in the Moderna phase III clinical trial, I collected my own biological samples pre- and post-immunization in the event of being a recipient of the experimental vaccine. The evidence strongly supports the conclusion that I did not receive the placebo. The analysis is admittedly limited to an n of 1, but the results fit well with data taken from published works and represent one of the more comprehensive longitudinal evaluations of vaccine-elicited immunity within a single individual yet to be undertaken. Though the data amount to a well-documented anecdote, given its granularity, it is not without its insights and may be of further use in directing future longitudinal studies that have actual statistical significance. Nature Publishing Group UK 2022-07-18 /pmc/articles/PMC9293989/ /pubmed/35851389 http://dx.doi.org/10.1038/s41541-022-00502-z Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Kedl, Ross M.
An immunological autobiography: my year as a COVID-19 vaccine trial participant
title An immunological autobiography: my year as a COVID-19 vaccine trial participant
title_full An immunological autobiography: my year as a COVID-19 vaccine trial participant
title_fullStr An immunological autobiography: my year as a COVID-19 vaccine trial participant
title_full_unstemmed An immunological autobiography: my year as a COVID-19 vaccine trial participant
title_short An immunological autobiography: my year as a COVID-19 vaccine trial participant
title_sort immunological autobiography: my year as a covid-19 vaccine trial participant
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293989/
https://www.ncbi.nlm.nih.gov/pubmed/35851389
http://dx.doi.org/10.1038/s41541-022-00502-z
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