Paracrine-mediated rejuvenation of aged mesenchymal stem cells is associated with downregulation of the autophagy-lysosomal pathway

Age-related differences in stem-cell potency contribute to variable outcomes in clinical stem cell trials. To help understand the effect of age on stem cell potency, bone marrow-derived mesenchymal stem cells (MSCs) were isolated from young (6 weeks) and old (18–24 months) mice. HUVEC tubule formati...

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Detalles Bibliográficos
Autores principales: Hung, George, Ashvetiya, Tamara, Leszczynska, Aleksandra, Yang, Wanjun, Hwang, Chao-Wei, Gerstenblith, Gary, Barth, Andreas S., Johnston, Peter V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293998/
https://www.ncbi.nlm.nih.gov/pubmed/35927427
http://dx.doi.org/10.1038/s41514-022-00091-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293998/
https://www.ncbi.nlm.nih.gov/pubmed/35927427
http://dx.doi.org/10.1038/s41514-022-00091-0

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