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Structural basis for the simultaneous recognition of NEMO and acceptor ubiquitin by the HOIP NZF1 domain

Ubiquitination of NEMO by the linear ubiquitin chain assembly complex (LUBAC) is essential for activating the canonical NF-κB signaling pathway. While the NZF1 domain of the HOIP subunit of LUBAC recognizes the NEMO substrate, it is unclear how it cooperates with the catalytic domains in the ubiquit...

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Detalles Bibliográficos
Autores principales:	Rahighi, Simin, Iyer, Mamta, Oveisi, Hamid, Nasser, Sammy, Duong, Vincent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294000/ https://www.ncbi.nlm.nih.gov/pubmed/35851409 http://dx.doi.org/10.1038/s41598-022-16193-4

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