Blocking GARP-mediated activation of TGF-β1 did not alter innate or adaptive immune responses to bacterial infection or protein immunization in mice

ABSTRACT: Transmembrane protein GARP binds latent TGF-β1 to form GARP:(latent)TGF-β1 complexes on the surface of several cell types including Tregs, B-cells, and platelets. Upon stimulation, these cells release active TGF-β1. Blocking TGF-β1 activation by Tregs with anti-GARP:TGF-β1 mAbs overcomes r...

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Detalles Bibliográficos
Autores principales: Gaignage, Mélanie, Zhang, Xuhao, Stockis, Julie, Dedobbeleer, Olivier, Michiels, Camille, Cochez, Perrine, Dumoutier, Laure, Coulie, Pierre G., Lucas, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294018/
https://www.ncbi.nlm.nih.gov/pubmed/34973084
http://dx.doi.org/10.1007/s00262-021-03119-8

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