Hypoxia-inducible factor-1 alpha expression is induced by IL-2 via the PI3K/mTOR pathway in hypoxic NK cells and supports effector functions in NKL cells and ex vivo expanded NK cells

Natural killer (NK) cells are cytotoxic innate lymphocytes that are specialized to kill tumor cells. NK cells are responsive to the primary cytokine IL-2 in the tumor microenvironment (TME), to activate its effector functions against tumors. Despite their inherent ability to kill tumor cells, dysfun...

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Detalles Bibliográficos
Autores principales: Cluff, Emily, Magdaleno, Carina C., Fernandez, Emyly, House, Trenton, Swaminathan, Srividya, Varadaraj, Archana, Rajasekaran, Narendiran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294031/
https://www.ncbi.nlm.nih.gov/pubmed/34999917
http://dx.doi.org/10.1007/s00262-021-03126-9

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