A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity

Increasing evidence has shown that Parkinson’s disease (PD) impairs midbrain dopaminergic, cortical and other neuronal subtypes in large part due to the build-up of lipid- and vesicle-rich α-synuclein (αSyn) cytotoxic inclusions. We previously identified stearoyl-CoA desaturase (SCD) as a potential...

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Detalles Bibliográficos
Autores principales: Nuber, Silke, Chung, Chee Yeun, Tardiff, Daniel F., Bechade, Pascal A., McCaffery, Thomas D., Shimanaka, Kazuma, Choi, Jeonghoon, Chang, Belle, Raja, Waseem, Neves, Esther, Burke, Christopher, Jiang, Xin, Xu, Ping, Khurana, Vikram, Dettmer, Ulf, Fanning, Saranna, Rhodes, Kenneth J., Selkoe, Dennis J., Scannevin, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294123/
https://www.ncbi.nlm.nih.gov/pubmed/35445353
http://dx.doi.org/10.1007/s13311-022-01199-7

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