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Pathogen-Derived Nucleases: An Effective Weapon for Escaping Extracellular Traps
Since the 2004 publication of the first study describing extracellular traps (ETs) from human neutrophils, several reports have shown the presence of ETs in a variety of different animals and plants. ETs perform two important functions of immobilizing and killing invading microbes and are considered...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294136/ https://www.ncbi.nlm.nih.gov/pubmed/35865526 http://dx.doi.org/10.3389/fimmu.2022.899890 |
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author | Liao, Chengshui Mao, Fuchao Qian, Man Wang, Xiaoli |
author_facet | Liao, Chengshui Mao, Fuchao Qian, Man Wang, Xiaoli |
author_sort | Liao, Chengshui |
collection | PubMed |
description | Since the 2004 publication of the first study describing extracellular traps (ETs) from human neutrophils, several reports have shown the presence of ETs in a variety of different animals and plants. ETs perform two important functions of immobilizing and killing invading microbes and are considered a novel part of the phagocytosis-independent, innate immune extracellular defense system. However, several pathogens can release nucleases that degrade the DNA backbone of ETs, reducing their effectiveness and resulting in increased pathogenicity. In this review, we examined the relevant literature and summarized the results on bacterial and fungal pathogens and parasites that produce nucleases to evade the ET-mediated host antimicrobial mechanism. |
format | Online Article Text |
id | pubmed-9294136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92941362022-07-20 Pathogen-Derived Nucleases: An Effective Weapon for Escaping Extracellular Traps Liao, Chengshui Mao, Fuchao Qian, Man Wang, Xiaoli Front Immunol Immunology Since the 2004 publication of the first study describing extracellular traps (ETs) from human neutrophils, several reports have shown the presence of ETs in a variety of different animals and plants. ETs perform two important functions of immobilizing and killing invading microbes and are considered a novel part of the phagocytosis-independent, innate immune extracellular defense system. However, several pathogens can release nucleases that degrade the DNA backbone of ETs, reducing their effectiveness and resulting in increased pathogenicity. In this review, we examined the relevant literature and summarized the results on bacterial and fungal pathogens and parasites that produce nucleases to evade the ET-mediated host antimicrobial mechanism. Frontiers Media S.A. 2022-07-05 /pmc/articles/PMC9294136/ /pubmed/35865526 http://dx.doi.org/10.3389/fimmu.2022.899890 Text en Copyright © 2022 Liao, Mao, Qian and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Liao, Chengshui Mao, Fuchao Qian, Man Wang, Xiaoli Pathogen-Derived Nucleases: An Effective Weapon for Escaping Extracellular Traps |
title | Pathogen-Derived Nucleases: An Effective Weapon for Escaping Extracellular Traps |
title_full | Pathogen-Derived Nucleases: An Effective Weapon for Escaping Extracellular Traps |
title_fullStr | Pathogen-Derived Nucleases: An Effective Weapon for Escaping Extracellular Traps |
title_full_unstemmed | Pathogen-Derived Nucleases: An Effective Weapon for Escaping Extracellular Traps |
title_short | Pathogen-Derived Nucleases: An Effective Weapon for Escaping Extracellular Traps |
title_sort | pathogen-derived nucleases: an effective weapon for escaping extracellular traps |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294136/ https://www.ncbi.nlm.nih.gov/pubmed/35865526 http://dx.doi.org/10.3389/fimmu.2022.899890 |
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