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Pathogen-Derived Nucleases: An Effective Weapon for Escaping Extracellular Traps

Since the 2004 publication of the first study describing extracellular traps (ETs) from human neutrophils, several reports have shown the presence of ETs in a variety of different animals and plants. ETs perform two important functions of immobilizing and killing invading microbes and are considered...

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Autores principales: Liao, Chengshui, Mao, Fuchao, Qian, Man, Wang, Xiaoli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294136/
https://www.ncbi.nlm.nih.gov/pubmed/35865526
http://dx.doi.org/10.3389/fimmu.2022.899890
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author Liao, Chengshui
Mao, Fuchao
Qian, Man
Wang, Xiaoli
author_facet Liao, Chengshui
Mao, Fuchao
Qian, Man
Wang, Xiaoli
author_sort Liao, Chengshui
collection PubMed
description Since the 2004 publication of the first study describing extracellular traps (ETs) from human neutrophils, several reports have shown the presence of ETs in a variety of different animals and plants. ETs perform two important functions of immobilizing and killing invading microbes and are considered a novel part of the phagocytosis-independent, innate immune extracellular defense system. However, several pathogens can release nucleases that degrade the DNA backbone of ETs, reducing their effectiveness and resulting in increased pathogenicity. In this review, we examined the relevant literature and summarized the results on bacterial and fungal pathogens and parasites that produce nucleases to evade the ET-mediated host antimicrobial mechanism.
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spelling pubmed-92941362022-07-20 Pathogen-Derived Nucleases: An Effective Weapon for Escaping Extracellular Traps Liao, Chengshui Mao, Fuchao Qian, Man Wang, Xiaoli Front Immunol Immunology Since the 2004 publication of the first study describing extracellular traps (ETs) from human neutrophils, several reports have shown the presence of ETs in a variety of different animals and plants. ETs perform two important functions of immobilizing and killing invading microbes and are considered a novel part of the phagocytosis-independent, innate immune extracellular defense system. However, several pathogens can release nucleases that degrade the DNA backbone of ETs, reducing their effectiveness and resulting in increased pathogenicity. In this review, we examined the relevant literature and summarized the results on bacterial and fungal pathogens and parasites that produce nucleases to evade the ET-mediated host antimicrobial mechanism. Frontiers Media S.A. 2022-07-05 /pmc/articles/PMC9294136/ /pubmed/35865526 http://dx.doi.org/10.3389/fimmu.2022.899890 Text en Copyright © 2022 Liao, Mao, Qian and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Liao, Chengshui
Mao, Fuchao
Qian, Man
Wang, Xiaoli
Pathogen-Derived Nucleases: An Effective Weapon for Escaping Extracellular Traps
title Pathogen-Derived Nucleases: An Effective Weapon for Escaping Extracellular Traps
title_full Pathogen-Derived Nucleases: An Effective Weapon for Escaping Extracellular Traps
title_fullStr Pathogen-Derived Nucleases: An Effective Weapon for Escaping Extracellular Traps
title_full_unstemmed Pathogen-Derived Nucleases: An Effective Weapon for Escaping Extracellular Traps
title_short Pathogen-Derived Nucleases: An Effective Weapon for Escaping Extracellular Traps
title_sort pathogen-derived nucleases: an effective weapon for escaping extracellular traps
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294136/
https://www.ncbi.nlm.nih.gov/pubmed/35865526
http://dx.doi.org/10.3389/fimmu.2022.899890
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