Cargando…

The Multifaceted Role of STAT3 in NK-Cell Tumor Surveillance

Signal transducer and activator of transcription 3 (STAT3) is a member of the Janus kinase (JAK)-STAT pathway, which is one of the key pathways contributing to cancer. STAT3 regulates transcription downstream of many cytokines including interleukin (IL)-6 and IL-10. In cancer, STAT3 is mainly descri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Witalisz-Siepracka, Agnieszka, Klein, Klara, Zdársky, Bernhard, Stoiber, Dagmar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294167/ https://www.ncbi.nlm.nih.gov/pubmed/35865518 http://dx.doi.org/10.3389/fimmu.2022.947568

Ejemplares similares

PB1783: UNRAVELING THE TUMOR SUPPRESSIVE ROLE OF STAT3B IN ACUTE MYELOID LEUKEMIA
por: Edtmayer, Sophie, et al.
Publicado: (2023)

PB1805: BREAKING A PARADIGM: LOSS OF STAT3 INCREASES INVASION IN MLL-AF9-DRIVEN ACUTE MYELOID LEUKEMIA
por: Zdársky, Bernhard, et al.
Publicado: (2023)

Untwining Anti-Tumor and Immunosuppressive Effects of JAK Inhibitors—A Strategy for Hematological Malignancies?
por: Klein, Klara, et al.
Publicado: (2021)

The Ups and Downs of STAT Inhibition in Acute Myeloid Leukemia
por: Moser, Bernhard, et al.
Publicado: (2021)

STAT1 Isoforms Differentially Regulate NK Cell Maturation and Anti-tumor Activity
por: Meissl, Katrin, et al.
Publicado: (2020)

PB1831: THE BALANCE BETWEEN STAT3 ISOFORMS AS ESSENTIAL FEATURE IN ACUTE MYELOID LEUKEMIA
por: Weiss, Stefanie, et al.
Publicado: (2023)

T Cell-Intrinsic CDK6 Is Dispensable for Anti-Viral and Anti-Tumor Responses In Vivo
por: Klein, Klara, et al.
Publicado: (2021)

Triple-negative breast cancer cells rely on kinase-independent functions of CDK8 to evade NK-cell-mediated tumor surveillance
por: Knab, Vanessa Maria, et al.
Publicado: (2021)

In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity
por: Prchal-Murphy, Michaela, et al.
Publicado: (2015)

Loss of NKG2D in murine NK cells leads to increased perforin production upon long‐term stimulation with IL‐2
por: Prinz, Daniela, et al.
Publicado: (2020)

Loss of JAK1 Drives Innate Immune Deficiency
por: Witalisz-Siepracka, Agnieszka, et al.
Publicado: (2019)

P1273: INVESTIGATING THE ONCOGENIC POTENTIAL OF STAT5BN642H IN NK CELLS
por: Klein, K., et al.
Publicado: (2022)

Editorial: Innate lymphocytes in tumor surveillance
por: Fritz, Jörg H., et al.
Publicado: (2022)

STATs in NK-Cells: The Good, the Bad, and the Ugly
por: Gotthardt, Dagmar, et al.
Publicado: (2017)

STAT5B(N642H) drives transformation of NKT cells: a novel mouse model for CD56(+) T-LGL leukemia
por: Klein, Klara, et al.
Publicado: (2019)

JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation
por: Gotthardt, Dagmar, et al.
Publicado: (2019)

CDK8-Novel Therapeutic Opportunities
por: Menzl, Ingeborg, et al.
Publicado: (2019)

The Transcription Factor ZNF683/HOBIT Regulates Human NK-Cell Development
por: Post, Mirte, et al.
Publicado: (2017)

Loss of STAT3 in Lymphoma Relaxes NK Cell-Mediated Tumor Surveillance
por: Putz, Eva Maria, et al.
Publicado: (2014)

NK Cell Anti-Tumor Surveillance in a Myeloid Cell-Shaped Environment
por: Russo, Eleonora, et al.
Publicado: (2021)

Allies or Enemies—The Multifaceted Role of Myeloid Cells in the Tumor Microenvironment
por: Haas, Lisa, et al.
Publicado: (2019)

An Update on the Multifaceted Roles of STAT3 in the Heart
por: Harhous, Zeina, et al.
Publicado: (2019)

Transcriptional, Epigenetic and Pharmacological Control of JAK/STAT Pathway in NK Cells
por: Scarno, Gianluca, et al.
Publicado: (2019)

CDK8-Mediated STAT1-S727 Phosphorylation Restrains NK Cell Cytotoxicity and Tumor Surveillance
por: Putz, Eva Maria, et al.
Publicado: (2013)

The multifaceted roles of NLRP3-modulating proteins in virus infection
por: Harris, James, et al.
Publicado: (2022)

NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation
por: Clark, Sarah E., et al.
Publicado: (2019)

Natural Killer Cells in Myeloid Malignancies: Immune Surveillance, NK Cell Dysfunction, and Pharmacological Opportunities to Bolster the Endogenous NK Cells
por: Carlsten, Mattias, et al.
Publicado: (2019)

The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies
por: Wang, Weiyuan, et al.
Publicado: (2023)

The Multifaceted Roles of STAT3 Signaling in the Progression of Prostate Cancer
por: Bishop, Jennifer L., et al.
Publicado: (2014)

Characterization of Surface Receptor Expression and Cytotoxicity of Human NK Cells and NK Cell Subsets in Overweight and Obese Humans
por: Naujoks, Wiebke, et al.
Publicado: (2020)

NK Cell Metabolism and Tumor Microenvironment
por: Terrén, Iñigo, et al.
Publicado: (2019)

NK cell exhaustion in the tumor microenvironment
por: Jia, Hao, et al.
Publicado: (2023)

The multifaceted Foxp3(fgfp) allele enhances spontaneous and therapeutic immune surveillance of cancer in mice
por: Almeida‐Santos, José, et al.
Publicado: (2019)

The multifaceted role of autophagy in tumor evasion from immune surveillance
por: Janji, Bassam, et al.
Publicado: (2016)

Evasion of NK cell immune surveillance via the vimentin-mediated cytoskeleton remodeling
por: Peng, Jei-Ming, et al.
Publicado: (2022)

Type I Interferons and Natural Killer Cell Regulation in Cancer
por: Müller, Lena, et al.
Publicado: (2017)

STAT1 Ser727 – key regulator for NK cell-mediated cytotoxicity and tumor surveillance
por: Putz, Eva M, et al.
Publicado: (2008)

Understanding the Multifaceted Role of Neutrophils in Cancer and Autoimmune Diseases
por: Wang, Xu, et al.
Publicado: (2018)

The multifaceted role of macrophages in homeostatic and injured skeletal muscle
por: Wang, Xingyu, et al.
Publicado: (2023)

The multifaceted role of macrophages during acute liver injury
por: Hassan, Ghada S., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rm8u5s2igqm34kca42q9s84e3t