Drug Resistance Mechanisms of Acute Myeloid Leukemia Stem Cells

Acute myeloid leukemia (AML) is a polyclonal and heterogeneous hematological malignancy. Relapse and refractory after induction chemotherapy are still challenges for curing AML. Leukemia stem cells (LSCs), accepted to originate from hematopoietic stem/precursor cells, are the main root of leukemogen...

Descripción completa

Detalles Bibliográficos
Autores principales: Niu, Jialan, Peng, Danyue, Liu, Lingbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294245/
https://www.ncbi.nlm.nih.gov/pubmed/35865470
http://dx.doi.org/10.3389/fonc.2022.896426
_version_ 1784749807614558208
author Niu, Jialan
Peng, Danyue
Liu, Lingbo
author_facet Niu, Jialan
Peng, Danyue
Liu, Lingbo
author_sort Niu, Jialan
collection PubMed
description Acute myeloid leukemia (AML) is a polyclonal and heterogeneous hematological malignancy. Relapse and refractory after induction chemotherapy are still challenges for curing AML. Leukemia stem cells (LSCs), accepted to originate from hematopoietic stem/precursor cells, are the main root of leukemogenesis and drug resistance. LSCs are dynamic derivations and possess various elusive resistance mechanisms. In this review, we summarized different primary resistance and remolding mechanisms of LSCs after chemotherapy, as well as the indispensable role of the bone marrow microenvironment on LSCs resistance. Through a detailed and comprehensive review of the spectacle of LSCs resistance, it can provide better strategies for future researches on eradicating LSCs and clinical treatment of AML.
format Online
Article
Text
id pubmed-9294245
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-92942452022-07-20 Drug Resistance Mechanisms of Acute Myeloid Leukemia Stem Cells Niu, Jialan Peng, Danyue Liu, Lingbo Front Oncol Oncology Acute myeloid leukemia (AML) is a polyclonal and heterogeneous hematological malignancy. Relapse and refractory after induction chemotherapy are still challenges for curing AML. Leukemia stem cells (LSCs), accepted to originate from hematopoietic stem/precursor cells, are the main root of leukemogenesis and drug resistance. LSCs are dynamic derivations and possess various elusive resistance mechanisms. In this review, we summarized different primary resistance and remolding mechanisms of LSCs after chemotherapy, as well as the indispensable role of the bone marrow microenvironment on LSCs resistance. Through a detailed and comprehensive review of the spectacle of LSCs resistance, it can provide better strategies for future researches on eradicating LSCs and clinical treatment of AML. Frontiers Media S.A. 2022-07-05 /pmc/articles/PMC9294245/ /pubmed/35865470 http://dx.doi.org/10.3389/fonc.2022.896426 Text en Copyright © 2022 Niu, Peng and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Niu, Jialan
Peng, Danyue
Liu, Lingbo
Drug Resistance Mechanisms of Acute Myeloid Leukemia Stem Cells
title Drug Resistance Mechanisms of Acute Myeloid Leukemia Stem Cells
title_full Drug Resistance Mechanisms of Acute Myeloid Leukemia Stem Cells
title_fullStr Drug Resistance Mechanisms of Acute Myeloid Leukemia Stem Cells
title_full_unstemmed Drug Resistance Mechanisms of Acute Myeloid Leukemia Stem Cells
title_short Drug Resistance Mechanisms of Acute Myeloid Leukemia Stem Cells
title_sort drug resistance mechanisms of acute myeloid leukemia stem cells
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294245/
https://www.ncbi.nlm.nih.gov/pubmed/35865470
http://dx.doi.org/10.3389/fonc.2022.896426
work_keys_str_mv AT niujialan drugresistancemechanismsofacutemyeloidleukemiastemcells
AT pengdanyue drugresistancemechanismsofacutemyeloidleukemiastemcells
AT liulingbo drugresistancemechanismsofacutemyeloidleukemiastemcells

Ejemplares similares