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Quality of Life and Mental Health Status Among Cancer Patients With Metastatic Spinal Disease

This study aimed to investigate the quality of life and mental health status and further to identify relevant risk factors among advanced cancer patients with spine metastases. This study prospectively included and analyzed 103 advanced cancer patients with spine metastases. Patient's basic inf...

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Autores principales: Liu, Yaosheng, Cao, Xuyong, Zhao, Xiongwei, Shi, Xiaolin, Lei, Mingxing, Qin, Haifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294283/
https://www.ncbi.nlm.nih.gov/pubmed/35865242
http://dx.doi.org/10.3389/fpubh.2022.916004
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author Liu, Yaosheng
Cao, Xuyong
Zhao, Xiongwei
Shi, Xiaolin
Lei, Mingxing
Qin, Haifeng
author_facet Liu, Yaosheng
Cao, Xuyong
Zhao, Xiongwei
Shi, Xiaolin
Lei, Mingxing
Qin, Haifeng
author_sort Liu, Yaosheng
collection PubMed
description This study aimed to investigate the quality of life and mental health status and further to identify relevant risk factors among advanced cancer patients with spine metastases. This study prospectively included and analyzed 103 advanced cancer patients with spine metastases. Patient's basic information, lifestyles, comorbidities, tumor characteristics, therapeutic strategies, economic conditions, quality of life, anxiety, and depression were collected. Patient's quality of life was assessed using the Functional Assessment of Cancer Therapy-General Scale (FACT-G), and anxiety and depression were evaluated using the Hospital Anxiety and Depression Scale (HADS). Subgroup analysis was performed based on different age groups, and a multivariate analysis was performed to test the ability of 20 potential risk factors to predict quality of life, anxiety, and depression. The mean total FACT-G score was only 61.38 ± 21.26. Of all included patients, 52.43% had skeptical or identified anxiety and 53.40% suffered from skeptical or identified depression. Patients had an age of 60 or more and <70 years had the lowest FACT-G score (54.91 ± 19.22), highest HADS anxiety score (10.25 ± 4.22), and highest HADS depression score (10.13 ± 4.94). After adjusting all other potential risk factors, age was still significantly associated with quality of life (OR = 0.57, 95%CI: 0.38–0.86, p < 0.01) and depression (OR = 1.55, 95%CI: 1.00–2.42, p = 0.05) and almost significantly associated with anxiety (OR = 1.52, 95%CI: 0.94–2.43, p = 0.08). Besides, preference to eating vegetables, time since knowing cancer diagnosis, surgical treatment at primary cancer, hormone endocrine therapy, and economic burden due to cancer treatments were found to be significantly associated with the quality of life. A number of comorbidities and economic burden due to cancer treatments were significantly associated with anxiety. Advanced cancer patients with spine metastases suffer from poor quality of life and severe anxiety and depression, especially among patients with an age of 60 or more and <70 years. Early mental health care and effective measures should be conducted to advanced cancer patients with spine metastases, and more attention should be paid to take care of patients with an age of 60 or more and <70 years in terms of their quality of life and mental health status.
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spelling pubmed-92942832022-07-20 Quality of Life and Mental Health Status Among Cancer Patients With Metastatic Spinal Disease Liu, Yaosheng Cao, Xuyong Zhao, Xiongwei Shi, Xiaolin Lei, Mingxing Qin, Haifeng Front Public Health Public Health This study aimed to investigate the quality of life and mental health status and further to identify relevant risk factors among advanced cancer patients with spine metastases. This study prospectively included and analyzed 103 advanced cancer patients with spine metastases. Patient's basic information, lifestyles, comorbidities, tumor characteristics, therapeutic strategies, economic conditions, quality of life, anxiety, and depression were collected. Patient's quality of life was assessed using the Functional Assessment of Cancer Therapy-General Scale (FACT-G), and anxiety and depression were evaluated using the Hospital Anxiety and Depression Scale (HADS). Subgroup analysis was performed based on different age groups, and a multivariate analysis was performed to test the ability of 20 potential risk factors to predict quality of life, anxiety, and depression. The mean total FACT-G score was only 61.38 ± 21.26. Of all included patients, 52.43% had skeptical or identified anxiety and 53.40% suffered from skeptical or identified depression. Patients had an age of 60 or more and <70 years had the lowest FACT-G score (54.91 ± 19.22), highest HADS anxiety score (10.25 ± 4.22), and highest HADS depression score (10.13 ± 4.94). After adjusting all other potential risk factors, age was still significantly associated with quality of life (OR = 0.57, 95%CI: 0.38–0.86, p < 0.01) and depression (OR = 1.55, 95%CI: 1.00–2.42, p = 0.05) and almost significantly associated with anxiety (OR = 1.52, 95%CI: 0.94–2.43, p = 0.08). Besides, preference to eating vegetables, time since knowing cancer diagnosis, surgical treatment at primary cancer, hormone endocrine therapy, and economic burden due to cancer treatments were found to be significantly associated with the quality of life. A number of comorbidities and economic burden due to cancer treatments were significantly associated with anxiety. Advanced cancer patients with spine metastases suffer from poor quality of life and severe anxiety and depression, especially among patients with an age of 60 or more and <70 years. Early mental health care and effective measures should be conducted to advanced cancer patients with spine metastases, and more attention should be paid to take care of patients with an age of 60 or more and <70 years in terms of their quality of life and mental health status. Frontiers Media S.A. 2022-07-05 /pmc/articles/PMC9294283/ /pubmed/35865242 http://dx.doi.org/10.3389/fpubh.2022.916004 Text en Copyright © 2022 Liu, Cao, Zhao, Shi, Lei and Qin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Liu, Yaosheng
Cao, Xuyong
Zhao, Xiongwei
Shi, Xiaolin
Lei, Mingxing
Qin, Haifeng
Quality of Life and Mental Health Status Among Cancer Patients With Metastatic Spinal Disease
title Quality of Life and Mental Health Status Among Cancer Patients With Metastatic Spinal Disease
title_full Quality of Life and Mental Health Status Among Cancer Patients With Metastatic Spinal Disease
title_fullStr Quality of Life and Mental Health Status Among Cancer Patients With Metastatic Spinal Disease
title_full_unstemmed Quality of Life and Mental Health Status Among Cancer Patients With Metastatic Spinal Disease
title_short Quality of Life and Mental Health Status Among Cancer Patients With Metastatic Spinal Disease
title_sort quality of life and mental health status among cancer patients with metastatic spinal disease
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294283/
https://www.ncbi.nlm.nih.gov/pubmed/35865242
http://dx.doi.org/10.3389/fpubh.2022.916004
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