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The Effects of Brain Magnetic Resonance Imaging Indices in the Association of Olfactory Identification and Cognition in Chinese Older Adults

BACKGROUND: Olfactory identification dysfunction frequently occurs in individuals with cognitive decline; however, a pathological mechanism linking the two has not been discovered. We aimed to study the association between olfactory identification and cognitive function, and determine the effects of...

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Autores principales: Tan, Ziyi, Wang, Yingzhe, Lu, Heyang, Tian, Weizhong, Xu, Kelin, Fan, Min, Zhao, Xiaolan, Jin, Li, Cui, Mei, Jiang, Yanfeng, Chen, Xingdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294318/
https://www.ncbi.nlm.nih.gov/pubmed/35865748
http://dx.doi.org/10.3389/fnagi.2022.873032
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author Tan, Ziyi
Wang, Yingzhe
Lu, Heyang
Tian, Weizhong
Xu, Kelin
Fan, Min
Zhao, Xiaolan
Jin, Li
Cui, Mei
Jiang, Yanfeng
Chen, Xingdong
author_facet Tan, Ziyi
Wang, Yingzhe
Lu, Heyang
Tian, Weizhong
Xu, Kelin
Fan, Min
Zhao, Xiaolan
Jin, Li
Cui, Mei
Jiang, Yanfeng
Chen, Xingdong
author_sort Tan, Ziyi
collection PubMed
description BACKGROUND: Olfactory identification dysfunction frequently occurs in individuals with cognitive decline; however, a pathological mechanism linking the two has not been discovered. We aimed to study the association between olfactory identification and cognitive function, and determine the effects of brain regions atrophy therein. METHODS: A total of 645 individuals (57.5% were female) from the Taizhou Imaging Study, who underwent cognitive and olfactory identification measurements, were included. A subsample of participants underwent brain magnetic resonance imaging (n = 622). Cognition was assessed with a neuropsychological battery. Olfactory identification was measured using a 12-item Sniffin’ Sticks test. Beta and logistic regressions were used to elucidate the association between olfactory identification and cognition, and the effects of brain regions atrophy in this association. RESULTS: Dementia was diagnosed in 41 (6.4%) individuals (mean age = 64.8 years), and mild cognitive impairment (MCI) in 157 (24.3%) individuals (mean age = 64.4 years). Olfactory identification was associated with MMSE and MoCA (both P < 0.001) and specific cognitive domains (memory, executive function, visuospatial function, and language; all P < 0.05). Higher olfactory identification was associated with lower likelihood of MCI and dementia (P < 0.05). The amygdala volume was significantly related to olfactory identification, MMSE, MoCA, and language, and could attenuate the association between olfactory identification and cognitive function. CONCLUSION: The association between olfactory identification and cognition can be partly attributable to differences in amygdala volume, suggesting that the amygdala could be a shared neural substrate that links olfactory identification and cognitive function. Limitations of this study include that all these results were based on a cross-sectional study.
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spelling pubmed-92943182022-07-20 The Effects of Brain Magnetic Resonance Imaging Indices in the Association of Olfactory Identification and Cognition in Chinese Older Adults Tan, Ziyi Wang, Yingzhe Lu, Heyang Tian, Weizhong Xu, Kelin Fan, Min Zhao, Xiaolan Jin, Li Cui, Mei Jiang, Yanfeng Chen, Xingdong Front Aging Neurosci Aging Neuroscience BACKGROUND: Olfactory identification dysfunction frequently occurs in individuals with cognitive decline; however, a pathological mechanism linking the two has not been discovered. We aimed to study the association between olfactory identification and cognitive function, and determine the effects of brain regions atrophy therein. METHODS: A total of 645 individuals (57.5% were female) from the Taizhou Imaging Study, who underwent cognitive and olfactory identification measurements, were included. A subsample of participants underwent brain magnetic resonance imaging (n = 622). Cognition was assessed with a neuropsychological battery. Olfactory identification was measured using a 12-item Sniffin’ Sticks test. Beta and logistic regressions were used to elucidate the association between olfactory identification and cognition, and the effects of brain regions atrophy in this association. RESULTS: Dementia was diagnosed in 41 (6.4%) individuals (mean age = 64.8 years), and mild cognitive impairment (MCI) in 157 (24.3%) individuals (mean age = 64.4 years). Olfactory identification was associated with MMSE and MoCA (both P < 0.001) and specific cognitive domains (memory, executive function, visuospatial function, and language; all P < 0.05). Higher olfactory identification was associated with lower likelihood of MCI and dementia (P < 0.05). The amygdala volume was significantly related to olfactory identification, MMSE, MoCA, and language, and could attenuate the association between olfactory identification and cognitive function. CONCLUSION: The association between olfactory identification and cognition can be partly attributable to differences in amygdala volume, suggesting that the amygdala could be a shared neural substrate that links olfactory identification and cognitive function. Limitations of this study include that all these results were based on a cross-sectional study. Frontiers Media S.A. 2022-07-05 /pmc/articles/PMC9294318/ /pubmed/35865748 http://dx.doi.org/10.3389/fnagi.2022.873032 Text en Copyright © 2022 Tan, Wang, Lu, Tian, Xu, Fan, Zhao, Jin, Cui, Jiang and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Tan, Ziyi
Wang, Yingzhe
Lu, Heyang
Tian, Weizhong
Xu, Kelin
Fan, Min
Zhao, Xiaolan
Jin, Li
Cui, Mei
Jiang, Yanfeng
Chen, Xingdong
The Effects of Brain Magnetic Resonance Imaging Indices in the Association of Olfactory Identification and Cognition in Chinese Older Adults
title The Effects of Brain Magnetic Resonance Imaging Indices in the Association of Olfactory Identification and Cognition in Chinese Older Adults
title_full The Effects of Brain Magnetic Resonance Imaging Indices in the Association of Olfactory Identification and Cognition in Chinese Older Adults
title_fullStr The Effects of Brain Magnetic Resonance Imaging Indices in the Association of Olfactory Identification and Cognition in Chinese Older Adults
title_full_unstemmed The Effects of Brain Magnetic Resonance Imaging Indices in the Association of Olfactory Identification and Cognition in Chinese Older Adults
title_short The Effects of Brain Magnetic Resonance Imaging Indices in the Association of Olfactory Identification and Cognition in Chinese Older Adults
title_sort effects of brain magnetic resonance imaging indices in the association of olfactory identification and cognition in chinese older adults
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294318/
https://www.ncbi.nlm.nih.gov/pubmed/35865748
http://dx.doi.org/10.3389/fnagi.2022.873032
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