Cargando…
A naturally occurring membrane-anchored Gα(s) variant, XLα(s), activates phospholipase Cβ4
Extra-large stimulatory Gα (XLα(s)) is a large variant of G protein α(s) subunit (Gα(s)) that uses an alternative promoter and thus differs from Gα(s) at the first exon. XLα(s) activation by G protein–coupled receptors mediates cAMP generation, similarly to Gα(s); however, Gα(s) and XLα(s) have been...
Autores principales: | Phan, Hoa T.N., Loomis, Joseph, Abraham, Saji, He, Qing, Bastepe, Murat, Smrcka, Alan V. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294334/ https://www.ncbi.nlm.nih.gov/pubmed/35709985 http://dx.doi.org/10.1016/j.jbc.2022.102134 |
Ejemplares similares
-
The GNAS Locus: Quintessential Complex Gene Encoding Gsα, XLαs, and other Imprinted Transcripts
por: Bastepe, Murat
Publicado: (2007) -
Maternal GNAS Contributes to the Extra-Large G Protein α-Subunit (XLαs) Expression in a Cell Type-Specific Manner
por: Cui, Quixia, et al.
Publicado: (2021) -
MON-LB087 Synthesis of Osteocyte-Derived Phosphaturic Hormone FGF23 via IP3/PKC Signaling Downstream of the Extra-Large Gα Subunit (XLαs)
por: He, Qing, et al.
Publicado: (2019) -
Stabilization of Interdomain Interactions in G protein α(i) Subunits Determines Gα(i) Subtype Signaling Specificity
por: Lefevre, Tyler J., et al.
Publicado: (2023) -
A Novel T55A Variant of G(s)
α Associated with Impaired cAMP Production, Bone Fragility, and Osteolysis
por: Wentworth, Kelly, et al.
Publicado: (2016)