The Chemistry of HNO: Mechanisms and Reaction Kinetics

Azanone (HNO, also known as nitroxyl) is the protonated form of the product of one-electron reduction of nitric oxide ((•)NO), and an elusive electrophilic reactive nitrogen species of increasing pharmacological significance. Over the past 20 years, the interest in the biological chemistry of HNO ha...

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Autores principales: Michalski, Radosław, Smulik-Izydorczyk, Renata, Pięta, Jakub, Rola, Monika, Artelska, Angelika, Pierzchała, Karolina, Zielonka, Jacek, Kalyanaraman, Balaraman, Sikora, Adam Bartłomiej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294461/
https://www.ncbi.nlm.nih.gov/pubmed/35864868
http://dx.doi.org/10.3389/fchem.2022.930657
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author Michalski, Radosław
Smulik-Izydorczyk, Renata
Pięta, Jakub
Rola, Monika
Artelska, Angelika
Pierzchała, Karolina
Zielonka, Jacek
Kalyanaraman, Balaraman
Sikora, Adam Bartłomiej
author_facet Michalski, Radosław
Smulik-Izydorczyk, Renata
Pięta, Jakub
Rola, Monika
Artelska, Angelika
Pierzchała, Karolina
Zielonka, Jacek
Kalyanaraman, Balaraman
Sikora, Adam Bartłomiej
author_sort Michalski, Radosław
collection PubMed
description Azanone (HNO, also known as nitroxyl) is the protonated form of the product of one-electron reduction of nitric oxide ((•)NO), and an elusive electrophilic reactive nitrogen species of increasing pharmacological significance. Over the past 20 years, the interest in the biological chemistry of HNO has increased significantly due to the numerous beneficial pharmacological effects of its donors. Increased availability of various HNO donors was accompanied by great progress in the understanding of HNO chemistry and chemical biology. This review is focused on the chemistry of HNO, with emphasis on reaction kinetics and mechanisms in aqueous solutions.
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spelling pubmed-92944612022-07-20 The Chemistry of HNO: Mechanisms and Reaction Kinetics Michalski, Radosław Smulik-Izydorczyk, Renata Pięta, Jakub Rola, Monika Artelska, Angelika Pierzchała, Karolina Zielonka, Jacek Kalyanaraman, Balaraman Sikora, Adam Bartłomiej Front Chem Chemistry Azanone (HNO, also known as nitroxyl) is the protonated form of the product of one-electron reduction of nitric oxide ((•)NO), and an elusive electrophilic reactive nitrogen species of increasing pharmacological significance. Over the past 20 years, the interest in the biological chemistry of HNO has increased significantly due to the numerous beneficial pharmacological effects of its donors. Increased availability of various HNO donors was accompanied by great progress in the understanding of HNO chemistry and chemical biology. This review is focused on the chemistry of HNO, with emphasis on reaction kinetics and mechanisms in aqueous solutions. Frontiers Media S.A. 2022-07-05 /pmc/articles/PMC9294461/ /pubmed/35864868 http://dx.doi.org/10.3389/fchem.2022.930657 Text en Copyright © 2022 Michalski, Smulik-Izydorczyk, Pięta, Rola, Artelska, Pierzchała, Zielonka, Kalyanaraman and Sikora. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Michalski, Radosław
Smulik-Izydorczyk, Renata
Pięta, Jakub
Rola, Monika
Artelska, Angelika
Pierzchała, Karolina
Zielonka, Jacek
Kalyanaraman, Balaraman
Sikora, Adam Bartłomiej
The Chemistry of HNO: Mechanisms and Reaction Kinetics
title The Chemistry of HNO: Mechanisms and Reaction Kinetics
title_full The Chemistry of HNO: Mechanisms and Reaction Kinetics
title_fullStr The Chemistry of HNO: Mechanisms and Reaction Kinetics
title_full_unstemmed The Chemistry of HNO: Mechanisms and Reaction Kinetics
title_short The Chemistry of HNO: Mechanisms and Reaction Kinetics
title_sort chemistry of hno: mechanisms and reaction kinetics
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294461/
https://www.ncbi.nlm.nih.gov/pubmed/35864868
http://dx.doi.org/10.3389/fchem.2022.930657
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