The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic mice

In this study, the optimal extraction conditions for the total flavonoids of Sedum aizoon L. (STF) were optimized by response surface methodology. Evaluation of the antioxidant in vitro of STF, and modulatory effects of glucolipid metabolism, and oxidative stress in mice with type 1 diabetes mellitu...

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Autores principales: Qi, Xin, Lu, Xin-tong, Sun, Xi-han, Lin, Chang-qing, Cui, Cheng-bi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles from the special issue: 6th International Symposium on Phytochemicals in Medicine and Food, edited by Jianbo Xiao, Jinping Si and Huifan Liu
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294556/
https://www.ncbi.nlm.nih.gov/pubmed/35865805
http://dx.doi.org/10.1016/j.crfs.2022.06.010
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author Qi, Xin
Lu, Xin-tong
Sun, Xi-han
Lin, Chang-qing
Cui, Cheng-bi
author_facet Qi, Xin
Lu, Xin-tong
Sun, Xi-han
Lin, Chang-qing
Cui, Cheng-bi
author_sort Qi, Xin
collection PubMed
description In this study, the optimal extraction conditions for the total flavonoids of Sedum aizoon L. (STF) were optimized by response surface methodology. Evaluation of the antioxidant in vitro of STF, and modulatory effects of glucolipid metabolism, and oxidative stress in mice with type 1 diabetes mellitus (T1DM). STF showed good antioxidant capacity in vitro. STF could improve glucolipid metabolism, organ coefficients, and antioxidant stress enzymes in T1DM mice effectively, reduce the damage to liver tissue, and regulate redox imbalance in the organism by modulating the Nrf2/Keap1/ARE signaling pathway. The results of this study could provide a theoretical reference for the application of Sedum aizoon L. in the development of auxiliary hypoglycemic functional foods and improvement of diabetes.
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spelling pubmed-92945562022-07-20 The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic mice Qi, Xin Lu, Xin-tong Sun, Xi-han Lin, Chang-qing Cui, Cheng-bi Curr Res Food Sci Articles from the special issue: 6th International Symposium on Phytochemicals in Medicine and Food, edited by Jianbo Xiao, Jinping Si and Huifan Liu In this study, the optimal extraction conditions for the total flavonoids of Sedum aizoon L. (STF) were optimized by response surface methodology. Evaluation of the antioxidant in vitro of STF, and modulatory effects of glucolipid metabolism, and oxidative stress in mice with type 1 diabetes mellitus (T1DM). STF showed good antioxidant capacity in vitro. STF could improve glucolipid metabolism, organ coefficients, and antioxidant stress enzymes in T1DM mice effectively, reduce the damage to liver tissue, and regulate redox imbalance in the organism by modulating the Nrf2/Keap1/ARE signaling pathway. The results of this study could provide a theoretical reference for the application of Sedum aizoon L. in the development of auxiliary hypoglycemic functional foods and improvement of diabetes. Elsevier 2022-07-08 /pmc/articles/PMC9294556/ /pubmed/35865805 http://dx.doi.org/10.1016/j.crfs.2022.06.010 Text en © 2022 Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Articles from the special issue: 6th International Symposium on Phytochemicals in Medicine and Food, edited by Jianbo Xiao, Jinping Si and Huifan Liu
Qi, Xin
Lu, Xin-tong
Sun, Xi-han
Lin, Chang-qing
Cui, Cheng-bi
The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic mice
title The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic mice
title_full The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic mice
title_fullStr The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic mice
title_full_unstemmed The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic mice
title_short The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic mice
title_sort regulatory effect of total flavonoids of sedum aizoon l. on oxidative stress in type 1 diabetic mice
topic Articles from the special issue: 6th International Symposium on Phytochemicals in Medicine and Food, edited by Jianbo Xiao, Jinping Si and Huifan Liu
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294556/
https://www.ncbi.nlm.nih.gov/pubmed/35865805
http://dx.doi.org/10.1016/j.crfs.2022.06.010
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