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Possible Effect of the use of Mesenchymal Stromal Cells in the Treatment of Autism Spectrum Disorders: A Review

Autism spectrum disorder (ASD) represents a set of heterogeneous neurodevelopmental conditions defined by impaired social interactions and repetitive behaviors. The number of reported cases has increased over the past decades, and ASD is now a major public health burden. So far, only treatments to a...

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Autores principales: Tamouza, Ryad, Volt, Fernanda, Richard, Jean-Romain, Wu, Ching-Lien, Bouassida, Jihène, Boukouaci, Wahid, Lansiaux, Pauline, Cappelli, Barbara, Scigliuolo, Graziana Maria, Rafii, Hanadi, Kenzey, Chantal, Mezouad, Esma, Naamoune, Soumia, Chami, Leila, Lejuste, Florian, Farge, Dominique, Gluckman, Eliane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294632/
https://www.ncbi.nlm.nih.gov/pubmed/35865626
http://dx.doi.org/10.3389/fcell.2022.809686
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author Tamouza, Ryad
Volt, Fernanda
Richard, Jean-Romain
Wu, Ching-Lien
Bouassida, Jihène
Boukouaci, Wahid
Lansiaux, Pauline
Cappelli, Barbara
Scigliuolo, Graziana Maria
Rafii, Hanadi
Kenzey, Chantal
Mezouad, Esma
Naamoune, Soumia
Chami, Leila
Lejuste, Florian
Farge, Dominique
Gluckman, Eliane
author_facet Tamouza, Ryad
Volt, Fernanda
Richard, Jean-Romain
Wu, Ching-Lien
Bouassida, Jihène
Boukouaci, Wahid
Lansiaux, Pauline
Cappelli, Barbara
Scigliuolo, Graziana Maria
Rafii, Hanadi
Kenzey, Chantal
Mezouad, Esma
Naamoune, Soumia
Chami, Leila
Lejuste, Florian
Farge, Dominique
Gluckman, Eliane
author_sort Tamouza, Ryad
collection PubMed
description Autism spectrum disorder (ASD) represents a set of heterogeneous neurodevelopmental conditions defined by impaired social interactions and repetitive behaviors. The number of reported cases has increased over the past decades, and ASD is now a major public health burden. So far, only treatments to alleviate symptoms are available, with still unmet need for an effective disease treatment to reduce ASD core symptoms. Genetic predisposition alone can only explain a small fraction of the ASD cases. It has been reported that environmental factors interacting with specific inter-individual genetic background may induce immune dysfunctions and contribute to the incidence of ASD. Such dysfunctions can be observed at the central level, with increased microglial cells and activation in ASD brains or in the peripheral blood, as reflected by high circulating levels of pro-inflammatory cytokines, abnormal activation of T-cell subsets, presence of auto-antibodies and of dysregulated microbiota profiles. Altogether, the dysfunction of immune processes may result from immunogenetically-determined inefficient immune responses against a given challenge followed by chronic inflammation and autoimmunity. In this context, immunomodulatory therapies might offer a valid therapeutic option. Mesenchymal stromal cells (MSC) immunoregulatory and immunosuppressive properties constitute a strong rationale for their use to improve ASD clinical symptoms. In vitro studies and pre-clinical models have shown that MSC can induce synapse formation and enhance synaptic function with consequent improvement of ASD-like symptoms in mice. In addition, two preliminary human trials based on the infusion of cord blood-derived MSC showed the safety and tolerability of the procedure in children with ASD and reported promising clinical improvement of core symptoms. We review herein the immune dysfunctions associated with ASD provided, the rationale for using MSC to treat patients with ASD and summarize the current available studies addressing this subject.
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spelling pubmed-92946322022-07-20 Possible Effect of the use of Mesenchymal Stromal Cells in the Treatment of Autism Spectrum Disorders: A Review Tamouza, Ryad Volt, Fernanda Richard, Jean-Romain Wu, Ching-Lien Bouassida, Jihène Boukouaci, Wahid Lansiaux, Pauline Cappelli, Barbara Scigliuolo, Graziana Maria Rafii, Hanadi Kenzey, Chantal Mezouad, Esma Naamoune, Soumia Chami, Leila Lejuste, Florian Farge, Dominique Gluckman, Eliane Front Cell Dev Biol Cell and Developmental Biology Autism spectrum disorder (ASD) represents a set of heterogeneous neurodevelopmental conditions defined by impaired social interactions and repetitive behaviors. The number of reported cases has increased over the past decades, and ASD is now a major public health burden. So far, only treatments to alleviate symptoms are available, with still unmet need for an effective disease treatment to reduce ASD core symptoms. Genetic predisposition alone can only explain a small fraction of the ASD cases. It has been reported that environmental factors interacting with specific inter-individual genetic background may induce immune dysfunctions and contribute to the incidence of ASD. Such dysfunctions can be observed at the central level, with increased microglial cells and activation in ASD brains or in the peripheral blood, as reflected by high circulating levels of pro-inflammatory cytokines, abnormal activation of T-cell subsets, presence of auto-antibodies and of dysregulated microbiota profiles. Altogether, the dysfunction of immune processes may result from immunogenetically-determined inefficient immune responses against a given challenge followed by chronic inflammation and autoimmunity. In this context, immunomodulatory therapies might offer a valid therapeutic option. Mesenchymal stromal cells (MSC) immunoregulatory and immunosuppressive properties constitute a strong rationale for their use to improve ASD clinical symptoms. In vitro studies and pre-clinical models have shown that MSC can induce synapse formation and enhance synaptic function with consequent improvement of ASD-like symptoms in mice. In addition, two preliminary human trials based on the infusion of cord blood-derived MSC showed the safety and tolerability of the procedure in children with ASD and reported promising clinical improvement of core symptoms. We review herein the immune dysfunctions associated with ASD provided, the rationale for using MSC to treat patients with ASD and summarize the current available studies addressing this subject. Frontiers Media S.A. 2022-07-05 /pmc/articles/PMC9294632/ /pubmed/35865626 http://dx.doi.org/10.3389/fcell.2022.809686 Text en Copyright © 2022 Tamouza, Volt, Richard, Wu, Bouassida, Boukouaci, Lansiaux, Cappelli, Scigliuolo, Rafii, Kenzey, Mezouad, Naamoune, Chami, Lejuste, Farge and Gluckman. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Tamouza, Ryad
Volt, Fernanda
Richard, Jean-Romain
Wu, Ching-Lien
Bouassida, Jihène
Boukouaci, Wahid
Lansiaux, Pauline
Cappelli, Barbara
Scigliuolo, Graziana Maria
Rafii, Hanadi
Kenzey, Chantal
Mezouad, Esma
Naamoune, Soumia
Chami, Leila
Lejuste, Florian
Farge, Dominique
Gluckman, Eliane
Possible Effect of the use of Mesenchymal Stromal Cells in the Treatment of Autism Spectrum Disorders: A Review
title Possible Effect of the use of Mesenchymal Stromal Cells in the Treatment of Autism Spectrum Disorders: A Review
title_full Possible Effect of the use of Mesenchymal Stromal Cells in the Treatment of Autism Spectrum Disorders: A Review
title_fullStr Possible Effect of the use of Mesenchymal Stromal Cells in the Treatment of Autism Spectrum Disorders: A Review
title_full_unstemmed Possible Effect of the use of Mesenchymal Stromal Cells in the Treatment of Autism Spectrum Disorders: A Review
title_short Possible Effect of the use of Mesenchymal Stromal Cells in the Treatment of Autism Spectrum Disorders: A Review
title_sort possible effect of the use of mesenchymal stromal cells in the treatment of autism spectrum disorders: a review
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294632/
https://www.ncbi.nlm.nih.gov/pubmed/35865626
http://dx.doi.org/10.3389/fcell.2022.809686
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