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Reduced Insulin Signaling Targeted to Serotonergic Neurons but Not Other Neuronal Subtypes Extends Lifespan in Drosophila melanogaster
Reduced Insulin/IGF-like signaling (IIS) plays an evolutionarily conserved role in improving longevity and some measures of health-span in model organisms. Recent studies, however, have found a disconnection between lifespan extension and behavioral health-span. We have previously shown that reducti...
Autores principales: | Dravecz, Nikolett, Shaw, Tommy, Davies, Isabella, Brown, Casey, Ormerod, Lewis, Vu, Gin, Walker, Tyler, Taank, Taran, Shirras, Alan D., Broughton, Susan J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294736/ https://www.ncbi.nlm.nih.gov/pubmed/35865744 http://dx.doi.org/10.3389/fnagi.2022.893444 |
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