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Applications of Vertebrate Models in Studying Prostatitis and Inflammation-Associated Prostatic Diseases

It has long been postulated that the inflammatory environment favors cell proliferation, and is conducive to diseases such as cancer. In the prostate gland, clinical data implicate important roles of prostatitis in the progression of both benign prostatic hyperplasia (BPH) and prostate cancer (PCa)....

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Autores principales: Bleeker, Joosje, Wang, Zhu A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294738/
https://www.ncbi.nlm.nih.gov/pubmed/35865005
http://dx.doi.org/10.3389/fmolb.2022.898871
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author Bleeker, Joosje
Wang, Zhu A.
author_facet Bleeker, Joosje
Wang, Zhu A.
author_sort Bleeker, Joosje
collection PubMed
description It has long been postulated that the inflammatory environment favors cell proliferation, and is conducive to diseases such as cancer. In the prostate gland, clinical data implicate important roles of prostatitis in the progression of both benign prostatic hyperplasia (BPH) and prostate cancer (PCa). However, their causal relationships have not been firmly established yet due to unresolved molecular and cellular mechanisms. By accurately mimicking human disease, vertebrate animals provide essential in vivo models to address this question. Here, we review the vertebrate prostatitis models that have been developed and discuss how they may reveal possible mechanisms by which prostate inflammation promotes BPH and PCa. Recent studies, particularly those involving genetically engineered mouse models (GEMMs), suggest that such mechanisms are multifaceted, which include epithelium barrier disruption, DNA damage and cell proliferation induced by paracrine signals, and expansion of potential cells of origin for cancer. Future research using rodent prostatitis models should aim to distinguish the etiologies of BPH and PCa, and facilitate the development of novel clinical approaches for prostatic disease prevention.
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spelling pubmed-92947382022-07-20 Applications of Vertebrate Models in Studying Prostatitis and Inflammation-Associated Prostatic Diseases Bleeker, Joosje Wang, Zhu A. Front Mol Biosci Molecular Biosciences It has long been postulated that the inflammatory environment favors cell proliferation, and is conducive to diseases such as cancer. In the prostate gland, clinical data implicate important roles of prostatitis in the progression of both benign prostatic hyperplasia (BPH) and prostate cancer (PCa). However, their causal relationships have not been firmly established yet due to unresolved molecular and cellular mechanisms. By accurately mimicking human disease, vertebrate animals provide essential in vivo models to address this question. Here, we review the vertebrate prostatitis models that have been developed and discuss how they may reveal possible mechanisms by which prostate inflammation promotes BPH and PCa. Recent studies, particularly those involving genetically engineered mouse models (GEMMs), suggest that such mechanisms are multifaceted, which include epithelium barrier disruption, DNA damage and cell proliferation induced by paracrine signals, and expansion of potential cells of origin for cancer. Future research using rodent prostatitis models should aim to distinguish the etiologies of BPH and PCa, and facilitate the development of novel clinical approaches for prostatic disease prevention. Frontiers Media S.A. 2022-07-05 /pmc/articles/PMC9294738/ /pubmed/35865005 http://dx.doi.org/10.3389/fmolb.2022.898871 Text en Copyright © 2022 Bleeker and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Bleeker, Joosje
Wang, Zhu A.
Applications of Vertebrate Models in Studying Prostatitis and Inflammation-Associated Prostatic Diseases
title Applications of Vertebrate Models in Studying Prostatitis and Inflammation-Associated Prostatic Diseases
title_full Applications of Vertebrate Models in Studying Prostatitis and Inflammation-Associated Prostatic Diseases
title_fullStr Applications of Vertebrate Models in Studying Prostatitis and Inflammation-Associated Prostatic Diseases
title_full_unstemmed Applications of Vertebrate Models in Studying Prostatitis and Inflammation-Associated Prostatic Diseases
title_short Applications of Vertebrate Models in Studying Prostatitis and Inflammation-Associated Prostatic Diseases
title_sort applications of vertebrate models in studying prostatitis and inflammation-associated prostatic diseases
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294738/
https://www.ncbi.nlm.nih.gov/pubmed/35865005
http://dx.doi.org/10.3389/fmolb.2022.898871
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