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Neuropilin Is a New Player in the Pathogenesis of COVID-19

Abstract—A family of glycoproteins called neuropilins is gaining attention as a new contributor to the pathogenesis of COVID-19. The concept of penetration of SARS-CoV-2 into host cells is traditionally associated with the receptor role of the ACE2 protein. New evidence suggests that it is possible...

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Autor principal: Gomazkov, O. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294753/
http://dx.doi.org/10.1134/S1819712422020064
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author Gomazkov, O. A.
author_facet Gomazkov, O. A.
author_sort Gomazkov, O. A.
collection PubMed
description Abstract—A family of glycoproteins called neuropilins is gaining attention as a new contributor to the pathogenesis of COVID-19. The concept of penetration of SARS-CoV-2 into host cells is traditionally associated with the receptor role of the ACE2 protein. New evidence suggests that it is possible to enhance pulmonary viral infection by involvement of neuropilins. Neuropilins have two prominent features: (a) a wide range of participation in cellular and tissue processes; (b) a concomitant enhancement of effects associated with the co-reception of regulatory proteins. These features determine the special role of functionally disseminated neuropilins in the pathogenesis of vascular system damage, immunothrombosis, and organ damage with comorbid manifestations during COVID-19. However, the presentation of neuropilins as a generalized therapeutic target that has a corrective effect on the affected areas is an ambiguous approach and requires a selective strategy.
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spelling pubmed-92947532022-07-19 Neuropilin Is a New Player in the Pathogenesis of COVID-19 Gomazkov, O. A. Neurochem. J. Review Articles Abstract—A family of glycoproteins called neuropilins is gaining attention as a new contributor to the pathogenesis of COVID-19. The concept of penetration of SARS-CoV-2 into host cells is traditionally associated with the receptor role of the ACE2 protein. New evidence suggests that it is possible to enhance pulmonary viral infection by involvement of neuropilins. Neuropilins have two prominent features: (a) a wide range of participation in cellular and tissue processes; (b) a concomitant enhancement of effects associated with the co-reception of regulatory proteins. These features determine the special role of functionally disseminated neuropilins in the pathogenesis of vascular system damage, immunothrombosis, and organ damage with comorbid manifestations during COVID-19. However, the presentation of neuropilins as a generalized therapeutic target that has a corrective effect on the affected areas is an ambiguous approach and requires a selective strategy. Pleiades Publishing 2022-07-18 2022 /pmc/articles/PMC9294753/ http://dx.doi.org/10.1134/S1819712422020064 Text en © Pleiades Publishing, Ltd. 2022, ISSN 1819-7124, Neurochemical Journal, 2022, Vol. 16, No. 2, pp. 130–135. © Pleiades Publishing, Ltd., 2022.Russian Text © The Author(s), 2022, published in Neirokhimiya, 2022, Vol. 39, No. 2, pp. 124–130. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Articles
Gomazkov, O. A.
Neuropilin Is a New Player in the Pathogenesis of COVID-19
title Neuropilin Is a New Player in the Pathogenesis of COVID-19
title_full Neuropilin Is a New Player in the Pathogenesis of COVID-19
title_fullStr Neuropilin Is a New Player in the Pathogenesis of COVID-19
title_full_unstemmed Neuropilin Is a New Player in the Pathogenesis of COVID-19
title_short Neuropilin Is a New Player in the Pathogenesis of COVID-19
title_sort neuropilin is a new player in the pathogenesis of covid-19
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294753/
http://dx.doi.org/10.1134/S1819712422020064
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