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Transplanted kidney loss during colorectal cancer chemotherapy: A case report

BACKGROUND: The overall risk of de novo malignancies in kidney transplant recipients (KTRs) is higher than that in the general population. It is associated with long-lasting exposure to immunosuppressive agents and impaired oncological vigilance due to chronic kidney disease. Colorectal cancer (CRC)...

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Autores principales: Pośpiech, Marta, Kolonko, Aureliusz, Nieszporek, Teresa, Kozak, Sylwia, Kozaczka, Anna, Karkoszka, Henryk, Winder, Mateusz, Chudek, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294886/
https://www.ncbi.nlm.nih.gov/pubmed/35979324
http://dx.doi.org/10.12998/wjcc.v10.i19.6647
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author Pośpiech, Marta
Kolonko, Aureliusz
Nieszporek, Teresa
Kozak, Sylwia
Kozaczka, Anna
Karkoszka, Henryk
Winder, Mateusz
Chudek, Jerzy
author_facet Pośpiech, Marta
Kolonko, Aureliusz
Nieszporek, Teresa
Kozak, Sylwia
Kozaczka, Anna
Karkoszka, Henryk
Winder, Mateusz
Chudek, Jerzy
author_sort Pośpiech, Marta
collection PubMed
description BACKGROUND: The overall risk of de novo malignancies in kidney transplant recipients (KTRs) is higher than that in the general population. It is associated with long-lasting exposure to immunosuppressive agents and impaired oncological vigilance due to chronic kidney disease. Colorectal cancer (CRC), frequently diagnosed in an advanced stage, is one of the most common malignancies in this cohort and is associated with poor prognosis. Still, because of the scarcity of data concerning adjuvant chemotherapy in this group, there are no clear guidelines for the specific management of the CRCs in KTRs. We present a patient who lost her transplanted kidney shortly after initiation of adjuvant chemotherapy for colon cancer. CASE SUMMARY: A 36-year-old woman with a medical history of kidney transplantation (2005) because of end-stage kidney disease, secondary to chronic glomerular nephritis, and long-term immunosuppression was diagnosed with locally advanced pT(4A)N(1B)M(0) (clinical stage III) colon adenocarcinoma G2. After right hemicolectomy, the patient was qualified to receive adjuvant chemotherapy that consisted of oxaliplatin, leucovorin and 5-fluorouracil (FOLFOX-4). The deterioration of kidney graft function after two cycles caused chemotherapy cessation and initiation of hemodialysis therapy after a few months. Shortly after that, the patient started palliative chemotherapy because of cancer recurrence with intraperitoneal spread. CONCLUSION: Initiation of adjuvant chemotherapy for colon cancer increases the risk of rapid kidney graft loss driven also by under-immunosuppression.
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spelling pubmed-92948862022-08-16 Transplanted kidney loss during colorectal cancer chemotherapy: A case report Pośpiech, Marta Kolonko, Aureliusz Nieszporek, Teresa Kozak, Sylwia Kozaczka, Anna Karkoszka, Henryk Winder, Mateusz Chudek, Jerzy World J Clin Cases Case Report BACKGROUND: The overall risk of de novo malignancies in kidney transplant recipients (KTRs) is higher than that in the general population. It is associated with long-lasting exposure to immunosuppressive agents and impaired oncological vigilance due to chronic kidney disease. Colorectal cancer (CRC), frequently diagnosed in an advanced stage, is one of the most common malignancies in this cohort and is associated with poor prognosis. Still, because of the scarcity of data concerning adjuvant chemotherapy in this group, there are no clear guidelines for the specific management of the CRCs in KTRs. We present a patient who lost her transplanted kidney shortly after initiation of adjuvant chemotherapy for colon cancer. CASE SUMMARY: A 36-year-old woman with a medical history of kidney transplantation (2005) because of end-stage kidney disease, secondary to chronic glomerular nephritis, and long-term immunosuppression was diagnosed with locally advanced pT(4A)N(1B)M(0) (clinical stage III) colon adenocarcinoma G2. After right hemicolectomy, the patient was qualified to receive adjuvant chemotherapy that consisted of oxaliplatin, leucovorin and 5-fluorouracil (FOLFOX-4). The deterioration of kidney graft function after two cycles caused chemotherapy cessation and initiation of hemodialysis therapy after a few months. Shortly after that, the patient started palliative chemotherapy because of cancer recurrence with intraperitoneal spread. CONCLUSION: Initiation of adjuvant chemotherapy for colon cancer increases the risk of rapid kidney graft loss driven also by under-immunosuppression. Baishideng Publishing Group Inc 2022-07-06 2022-07-06 /pmc/articles/PMC9294886/ /pubmed/35979324 http://dx.doi.org/10.12998/wjcc.v10.i19.6647 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Case Report
Pośpiech, Marta
Kolonko, Aureliusz
Nieszporek, Teresa
Kozak, Sylwia
Kozaczka, Anna
Karkoszka, Henryk
Winder, Mateusz
Chudek, Jerzy
Transplanted kidney loss during colorectal cancer chemotherapy: A case report
title Transplanted kidney loss during colorectal cancer chemotherapy: A case report
title_full Transplanted kidney loss during colorectal cancer chemotherapy: A case report
title_fullStr Transplanted kidney loss during colorectal cancer chemotherapy: A case report
title_full_unstemmed Transplanted kidney loss during colorectal cancer chemotherapy: A case report
title_short Transplanted kidney loss during colorectal cancer chemotherapy: A case report
title_sort transplanted kidney loss during colorectal cancer chemotherapy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294886/
https://www.ncbi.nlm.nih.gov/pubmed/35979324
http://dx.doi.org/10.12998/wjcc.v10.i19.6647
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