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Inhibiting DHN- and DOPA-melanin biosynthesis pathway increased the therapeutic value of itraconazole in Madurella mycetomatis infected Galleria mellonella

Eumycetoma is a neglected tropical disease, and Madurella mycetomatis, the most common causative agent of this disease forms black grains in hosts. Melanin was discovered to be one of the constituents in grains. Melanins are hydrophobic, macromolecular pigments formed by oxidative polymerisation of...

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Detalles Bibliográficos
Autores principales:	Lim, Wilson, Konings, Mickey, Parel, Florianne, Eadie, Kimberly, Strepis, Nikolaos, Fahal, Ahmed, Verbon, Annelies, van de Sande, Wendy W J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295015/ https://www.ncbi.nlm.nih.gov/pubmed/35064672 http://dx.doi.org/10.1093/mmy/myac003

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