The Role of DACT Family Members in Tumorigenesis and Tumor Progression

Disheveled-associated antagonist of β-catenin (DACT), which ubiquitously expressed in human tissue, is critical for regulating cell proliferation and several developmental processes in different cellular contexts. In addition, DACT is essential for some other cellular processes, such as cell apoptos...

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Autores principales: Zeng, Yu, Zhang, Jiqin, Yue, Jianhe, Han, Guoqiang, Liu, Weijia, Liu, Lin, Lin, Xin, Zha, Yan, Liu, Jian, Tan, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295065/
https://www.ncbi.nlm.nih.gov/pubmed/35864965
http://dx.doi.org/10.7150/ijbs.70784
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author Zeng, Yu
Zhang, Jiqin
Yue, Jianhe
Han, Guoqiang
Liu, Weijia
Liu, Lin
Lin, Xin
Zha, Yan
Liu, Jian
Tan, Ying
author_facet Zeng, Yu
Zhang, Jiqin
Yue, Jianhe
Han, Guoqiang
Liu, Weijia
Liu, Lin
Lin, Xin
Zha, Yan
Liu, Jian
Tan, Ying
author_sort Zeng, Yu
collection PubMed
description Disheveled-associated antagonist of β-catenin (DACT), which ubiquitously expressed in human tissue, is critical for regulating cell proliferation and several developmental processes in different cellular contexts. In addition, DACT is essential for some other cellular processes, such as cell apoptosis, migration and differentiation. Given the importance of DACT in these cellular processes, many scientists are gradually interested in studying the role of DACT in tumorigenesis and cancer progression. This review article focuses on the latest research regarding the essential functions and potential DACT mechanisms in the occurrence and progression of tumors. Our study indicates that DACT may act as a tumor biomarker for cancer diagnosis and prognosis, as well as a promising therapeutic target in cancers.
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spelling pubmed-92950652022-07-20 The Role of DACT Family Members in Tumorigenesis and Tumor Progression Zeng, Yu Zhang, Jiqin Yue, Jianhe Han, Guoqiang Liu, Weijia Liu, Lin Lin, Xin Zha, Yan Liu, Jian Tan, Ying Int J Biol Sci Review Disheveled-associated antagonist of β-catenin (DACT), which ubiquitously expressed in human tissue, is critical for regulating cell proliferation and several developmental processes in different cellular contexts. In addition, DACT is essential for some other cellular processes, such as cell apoptosis, migration and differentiation. Given the importance of DACT in these cellular processes, many scientists are gradually interested in studying the role of DACT in tumorigenesis and cancer progression. This review article focuses on the latest research regarding the essential functions and potential DACT mechanisms in the occurrence and progression of tumors. Our study indicates that DACT may act as a tumor biomarker for cancer diagnosis and prognosis, as well as a promising therapeutic target in cancers. Ivyspring International Publisher 2022-07-11 /pmc/articles/PMC9295065/ /pubmed/35864965 http://dx.doi.org/10.7150/ijbs.70784 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Zeng, Yu
Zhang, Jiqin
Yue, Jianhe
Han, Guoqiang
Liu, Weijia
Liu, Lin
Lin, Xin
Zha, Yan
Liu, Jian
Tan, Ying
The Role of DACT Family Members in Tumorigenesis and Tumor Progression
title The Role of DACT Family Members in Tumorigenesis and Tumor Progression
title_full The Role of DACT Family Members in Tumorigenesis and Tumor Progression
title_fullStr The Role of DACT Family Members in Tumorigenesis and Tumor Progression
title_full_unstemmed The Role of DACT Family Members in Tumorigenesis and Tumor Progression
title_short The Role of DACT Family Members in Tumorigenesis and Tumor Progression
title_sort role of dact family members in tumorigenesis and tumor progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295065/
https://www.ncbi.nlm.nih.gov/pubmed/35864965
http://dx.doi.org/10.7150/ijbs.70784
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